Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide KATP Channel Openers: Discovery of (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637), a Potent KATP Opener That Selectively Inhibits Spontaneous Bladder Contractions
Carroll, William A., Altenbach, Robert J., Bai, Hao, Brioni, Jorge D., Brune, Michael E., Buckner, Steven A., Cassidy, Christopher, Chen, Yiyuan, Coghlan, Michael J., Daza, Anthony V.Volume:
47
Year:
2004
Language:
english
Pages:
17
DOI:
10.1021/jm030356w
File:
PDF, 282 KB
english, 2004