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Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O6-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance
Raymond P. Baumann, Philip G. Penketh, Kimiko Ishiguro, Krishnamurthy Shyam, Yong L. Zhu, Alan C. SartorelliVolume:
79
Year:
2010
Language:
english
Pages:
9
DOI:
10.1016/j.bcp.2009.12.004
File:
PDF, 301 KB
english, 2010