Reply to David Connolly, Rachel Hutton, Patrick F. Keane's Letter to the Editor re: Monique J. Roobol, Fritz H. Schröder, Pim van Leeuwen, et al. Performance of the Prostate Cancer Antigen 3 (PCA3) Gene and Prostate-Specific Antigen in Prescreened Men: Exploring the Value of PCA3 for a First-line Diagnostic Test. Eur Urol 2010;58:475–81

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