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Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)
Wissner, Allan, Overbeek, Elsebe, Reich, Marvin F., Floyd, M. Brawner, Johnson, Bernard D., Mamuya, Nellie, Rosfjord, Edward C., Discafani, Carolyn, Davis, Rachel, Shi, Xiaoqing, Rabindran, Sridhar K.Volume:
46
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm020241c
Date:
January, 2003
File:
PDF, 410 KB
english, 2003