Discovery of a Series of 2-Phenyl- N...

Journal of Medicinal Chemistry 2012 / 08 Vol. 55; Iss. 15

Discovery of a Series of 2-Phenyl- N -(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of K v 7.2 (KCNQ2) Channel Pharmacology: Identification of ( S )-2-Phenyl- N -(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant K v 7.2 Channel Inhibitor

Cheung, Yiu-Yin, Yu, Haibo, Xu, Kaiping, Zou, Beiyan, Wu, Meng, McManus, Owen B., Li, Min, Lindsley, Craig W., Hopkins, Corey R.
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Volume:
55
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm300700v
Date:
August, 2012
File:
PDF, 470 KB
english, 2012
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