Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV....

Journal of Medicinal Chemistry 2004 / 05 Vol. 47; Iss. 10

Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1( R )-4-(trifluoromethyl)phenyl}ethyl-3( S )-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a Potent, Highly Selective, and Orally Bioavailable CCR5 Antagonist

Tagat, Jayaram R., McCombie, Stuart W., Nazareno, Dennis, Labroli, Marc A., Xiao, Yushi, Steensma, Ruo W., Strizki, Julie M., Baroudy, Bahige M., Cox, Kathleen, Lachowicz, Jean, Varty, Geoffrey, Watki
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Volume:
47
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm0304515
Date:
May, 2004
File:
PDF, 78 KB
english, 2004
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