Reductions in log P Improved Protein Binding and Clearance Predictions Enabling the Prospective Design of Cannabinoid Receptor (CB1) Antagonists with Desired Pharmacokinetic Properties
Ellsworth, Bruce A., Sher, Philip M., Wu, Ximao, Wu, Gang, Sulsky, Richard B., Gu, Zhengxiang, Murugesan, Natesan, Zhu, Yeheng, Yu, Guixue, Sitkoff, Doree F., Carlson, Kenneth E., Kang, Liya, Yang, YiVolume:
56
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm4010835
Date:
December, 2013
File:
PDF, 1.35 MB
english, 2013