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Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
Ioanoviciu, Alexandra, Antony, Smitha, Pommier, Yves, Staker, Bart L., Stewart, Lance, Cushman, MarkVolume:
48
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm050076b
Date:
July, 2005
File:
PDF, 700 KB
english, 2005