Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor
Nakamura, Yuji, Fujimoto, Teppei, Ogawa, Yasuyuki, Namiki, Hidenori, Suzuki, Sayaka, Asano, Masayoshi, Sugita, Chie, Mochizuki, Akiyoshi, Miyazaki, Shojiro, Tamaki, Kazuhiko, Nagai, Yoko, Inoue, Shin-Volume:
21
Language:
english
Journal:
Bioorganic & Medicinal Chemistry
DOI:
10.1016/j.bmc.2013.03.022
Date:
June, 2013
File:
PDF, 4.72 MB
english, 2013
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