Discovery of 5-Substituted Pyrrolo[2,3- d ]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity
Mitchell-Ryan, Shermaine, Wang, Yiqiang, Raghavan, Sudhir, Ravindra, Manasa Punaha, Hales, Eric, Orr, Steven, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H., Gangjee, AleemVolume:
56
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm401328u
Date:
December, 2013
File:
PDF, 3.92 MB
english, 2013