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Imidazoquinoxaline Src-Family Kinase p56 Lck Inhibitors: SAR, QSAR, and the Discovery of ( S )- N -(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5- a ]pyrido[3,2- e ]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity
Chen, Ping, Doweyko, Arthur M., Norris, Derek, Gu, Henry H., Spergel, Steven H., Das, Jagabundhu, Moquin, Robert V., Lin, James, Wityak, John, Iwanowicz, Edwin J., McIntyre, Kim W., Shuster, David J.,Volume:
47
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm030217e
Date:
August, 2004
File:
PDF, 370 KB
english, 2004