Structure–Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4-[3-Chloro-5-[(1 S )-1,2-dihydroxyethyl]-2-pyridyl]- N -[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2 H -pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management

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