Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity
Lee, Jeewoo, Han, Kee-Chung, Kang, Ji-Hye, Pearce, Larry L., Lewin, Nancy E., Yan, Shunqi, Benzaria, Samira, Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.Volume:
44
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm0103965
Date:
December, 2001
File:
PDF, 93 KB
english, 2001