Discovery and Clinical Evaluation of 1-{ N -[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a Thrombin Inhibitor with an Oxyguanidine P1 Motif
Lu, Tianbao, Markotan, Thomas, Ballentine, Shelley K., Giardino, Edward C., Spurlino, John, Brown, Kathryn, Maryanoff, Bruce E., Tomczuk, Bruce E., Damiano, Bruce P., Shukla, Umesh, End, David, AndradVolume:
53
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm901802n
Date:
February, 2010
File:
PDF, 3.42 MB
english, 2010