Why is the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine in its diphosphorylated form (PMEApp4−) initially a better substrate for polymerases than (2′-deoxy)adenosine 5′-triphosphate (dATP4−/ATP4−)? Considerations on the mechanism of nucleic acid polymerases
Sigel, Helmut, Song, Bin, Blindauer, Claudia A., Kapinos, Larisa E., Gregáň, Fridrich, Prónayová, NadjaYear:
1999
Language:
english
Journal:
Chemical Communications
DOI:
10.1039/a901233h
File:
PDF, 145 KB
english, 1999