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Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate
Kodaira, H., Kusuhara, H., Fujita, T., Ushiki, J., Fuse, E., Sugiyama, Y.Volume:
339
Language:
english
Journal:
Journal of Pharmacology and Experimental Therapeutics
DOI:
10.1124/jpet.111.180398
Date:
December, 2011
File:
PDF, 628 KB
english, 2011