Discovery of ( R )-1-(3-((2-Chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1′-Biphenyl]-2-ylcarbamate (TD-5959, GSK961081, Batefenterol): First-in-Class Dual Pharmacology Multivalent Muscarinic Antagonist and β 2 Agonist (MABA) for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Hughes, Adam D., Chen, Yan, Hegde, Sharath S., Jasper, Jeffrey R., Jaw-Tsai, Sarah, Lee, Tae-Weon, McNamara, Alexander, Pulido-Rios, M. Teresa, Steinfeld, Tod, Mammen, MathaiVolume:
58
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/jm501915g
Date:
March, 2015
File:
PDF, 3.19 MB
english, 2015