Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases
Daniel Best, Chen Wang, Alexander C. Weymouth-Wilson, Robert A. Clarkson, Francis X. Wilson, Robert J. Nash, Saori Miyauchi, Atsushi Kato, George W.J. FleetVolume:
21
Year:
2010
Language:
english
Pages:
9
DOI:
10.1016/j.tetasy.2010.01.017
File:
PDF, 592 KB
english, 2010