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Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates
van Geel, Remon, Wijdeven, Marloes A., Heesbeen, Ryan, Verkade, Jorge M. M., Wasiel, Anna A., van Berkel, Sander S., van Delft, Floris L.Language:
english
Journal:
Bioconjugate Chemistry
DOI:
10.1021/acs.bioconjchem.5b00224
Date:
June, 2015
File:
PDF, 1.47 MB
english, 2015