Discovery of 1-{4-[3-Fluoro-4-((3 S ,6 R )-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist
Fauber, Benjamin P., René, Olivier, Deng, Yuzhong, DeVoss, Jason, Eidenschenk, Céline, Everett, Christine, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., La, Hank, Lesch, Justin,Volume:
58
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.5b00597
Date:
July, 2015
File:
PDF, 2.23 MB
english, 2015