NF2 loss promotes oncogenic RAS-induced thyroid cancers via YAP-dependent transactivation of RAS proteins and sensitizes them to MEK inhibition.
Garcia-Rendueles, M. E. R., Ricarte-Filho, J. C., Untch, B. R., Landa, I., Knauf, J. A., Voza, F., Smith, V. E., Ganly, I., Taylor, B. S., Persaud, Y., Oler, G., Fang, Y., Jhanwar, S. C., Viale, A., HLanguage:
english
Journal:
Cancer Discovery
DOI:
10.1158/2159-8290.CD-15-0330
Date:
September, 2015
File:
PDF, 2.34 MB
english, 2015