Verification of the major metabolic oxidation path for the naphthoyl group in chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2) antagonist 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1 H -pyrido[4,3- b ]indol-5(2 H )-yl)acetic acid (Setipiprant/ACT-129968)
Risch, Philippe, Pfeifer, Thomas, Segrestaa, Jerome, Fretz, Heinz, Pothier, JulienLanguage:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.5b00824
Date:
September, 2015
File:
PDF, 2.20 MB
english, 2015