IL23R variants protective against inflammatory bowel diseases (IBD) display loss of function due to impaired protein stability and intracellular trafficking.
Sivanesan, Durga, Beauchamp, Claudine, Quinou, Christiane, Lee, Jonathan, Lesage, Sylvie, Chemtob, Sylvain, Rioux, John D., Michnick, StephenLanguage:
english
Journal:
Journal of Biological Chemistry
DOI:
10.1074/jbc.m116.715870
Date:
February, 2016
File:
PDF, 6.56 MB
english, 2016