Optimization of the phenylurea moiety in a phosphoinositide...

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Bioorganic & Medicinal Chemistry 2016 / 4

Optimization of the phenylurea moiety in a phosphoinositide 3kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents

Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shimma, Nobuo, Tsukuda, Taku
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Language:
english
Journal:
Bioorganic & Medicinal Chemistry
DOI:
10.1016/j.bmc.2016.04.060
Date:
April, 2016
File:
PDF, 2.59 MB
english, 2016
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