Discovery of ( R ,...

Journal of Medicinal Chemistry 2016 / 07 Vol. 59; Iss. 14

Discovery of ( R , E )- N -(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1 H -benzo[ d ]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers

Lelais, Gérald, Epple, Robert, Marsilje, Thomas H., Long, Yun O., McNeill, Matthew, Chen, Bei, Lu, Wenshuo, Anumolu, Jaganmohan, Badiger, Sangamesh, Bursulaya, Badry, DiDonato, Michael, Fong, Rina, Ju
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Volume:
59
Language:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.5b01985
Date:
July, 2016
File:
PDF, 3.31 MB
english, 2016
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