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Discovery of N -[bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617) an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1−3 (HIF PHD1−3) for the Treatment of Anemia.
Debenham, John S, Madsen-Duggan, Christina B., Clements, Matthew J., Walsh, Thomas F., Kuethe, Jeffrey T, Reibarkh, Mikhail, Salowe, Scott P., Sonatore, Lisa M., Hajdu, Richard, Milligan, James A., ViLanguage:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.6b01242
Date:
November, 2016
File:
PDF, 2.47 MB
english, 2016