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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 6. Synthesis of the C1-C15 Unit via Stereoselective Construction of the B and A Rings by Kinetically and Thermodynamically Controlled Michael Reactions with the Aid of Computational Search for Dominant Conformers.
HORITA, Kiyoshi, HACHIYA, Shun-ichiro, YAMAZAKI, Tatsuya, NAITOU, Tae, UENISHI, Jun'ichi, YONEMITSU, OsamuVolume:
45
Year:
1997
Journal:
CHEMICAL & PHARMACEUTICAL BULLETIN
DOI:
10.1248/cpb.45.1265
File:
PDF, 2.65 MB
1997