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Analysis of the change in the blood concentration–time profile caused by complex drug–drug interactions in the liver considering the enterohepatic circulation: Examining whether the inhibition constants for uptake, metabolism and biliary excretion can be recovered by the analyses using physiologically based pharmacokinetic modeling
Toshimoto, Kota, Tomoda, Yukana, Chiba, Koji, Sugiyama, YuichiLanguage:
english
Journal:
Journal of Pharmaceutical Sciences
DOI:
10.1016/j.xphs.2017.04.057
Date:
May, 2017
File:
PDF, 559 KB
english, 2017