Monoamine oxidase B oxidizes a novel multikinase inhibitor...

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Drug Metabolism and Pharmacokinetics 2017 / 6

Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human

Hosogi, Jun, Ohashi, Rui, Maeda, Hiroshi, Tashiro, Satoshi, Fuse, Eiichi, Yamamoto, Yorihiro, Kuwabara, Takashi
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Language:
english
Journal:
Drug Metabolism and Pharmacokinetics
DOI:
10.1016/j.dmpk.2017.06.002
Date:
June, 2017
File:
PDF, 1.30 MB
english, 2017
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