Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis
Ravindra, Manasa, Wallace-Povirk, Adrianne, Karim, Mohammad A., Wilson, Mike R., O'Connor, Carrie E, White, Kathryn, Kushner, Juiwanna, Polin, Lisa A., George, Christina, Hou, Zhanjun, Matherly, LarryLanguage:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.7b01708
Date:
February, 2018
File:
PDF, 1.47 MB
english, 2018