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Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex
Kiyoshi, Masato, Caaveiro, Jose M. M., Miura, Eri, Nagatoishi, Satoru, Nakakido, Makoto, Soga, Shinji, Shirai, Hiroki, Kawabata, Shigeki, Tsumoto, Kouhei, Buckle, Ashley M.Volume:
9
Language:
english
Journal:
PLoS ONE
DOI:
10.1371/journal.pone.0087099
Date:
January, 2014
File:
PDF, 1.11 MB
english, 2014