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Discovery of novel central nervous system penetrant metabotropic glutamate receptor subtype 2 (mGlu 2 ) Negative Allosteric Modulators (NAMs) based on functionalized pyrazolo[1,5- a ]pyrimidine-5-carboxamide and thieno[3,2- b ]pyridine-5-carboxamide cores
Childress, Elizabeth S, Wieting, Joshua M., Felts, Andrew S, Breiner, Megan M, Long, Madeline F, Luscombe, Vincent B, Rodriguez, Alice L, Cho, Hyekyung P., Blobaum, Anna L., Niswender, Colleen M, EmmiLanguage:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.8b01266
Date:
October, 2018
File:
PDF, 1.31 MB
english, 2018