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Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7
Zoppi, Vittoria, Hughes, Scott J, Maniaci, Chiara, TESTA, ANDREA, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin, Daniels, Danette L., Spallarossa, Andrea, Ciulli, AlessioLanguage:
english
Journal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.8b01413
Date:
December, 2018
File:
PDF, 7.27 MB
english, 2018