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Protocol-dependent differences in IC50 values measured in hERG assays occur in a predictable way and can be used to quantify state preference of drug binding.
Lee, William, Windley, Monique J, Perry, Matthew D, Vandenberg, Jamie I, Hill, AdamLanguage:
english
Journal:
Molecular Pharmacology
DOI:
10.1124/mol.118.115220
Date:
February, 2019
File:
PDF, 11.84 MB
english, 2019