Cyclization of N-Terminal Glutamic Acid to pyro-Glutamic Acid Impacts Monoclonal Antibody Charge Heterogeneity Despite Its Appearance as a Neutral Transformation
Liu, Zhihua, Valente, Joseph, Lin, Shujie, Chennamsetty, Naresh, Qiu, Difei, Bolgar, MarkLanguage:
english
Journal:
Journal of Pharmaceutical Sciences
DOI:
10.1016/j.xphs.2019.05.023
Date:
May, 2019
File:
PDF, 875 KB
english, 2019