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Frequent and persistent PLCG1 mutations in Sézary cells directly enhance PLCγ1 activity and stimulate NFκB, AP-1 and NFAT signaling. Short title: Gain-of-function PLCG1 mutations in Sézary Syndrome
Patel, Varsha M., Flanagan, Charlotte E., Martins, Marta, Jones, Christine L., Butler, Rosie M., Woollard, Wesley J., Bakr, Farrah S., Yoxall, Antoinette, Begum, Nelema, Katan, Matilda, Whittaker, SeaLanguage:
english
Journal:
Journal of Investigative Dermatology
DOI:
10.1016/j.jid.2019.07.693
Date:
July, 2019
File:
PDF, 4.02 MB
english, 2019