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Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP
Lu, Tsan-Wen, Wu, Jian, Aoto, Phillip C., Weng, Jui-Hung, Ahuja, Lalima G., Sun, Nicholas, Cheng, Cecilia Y., Zhang, Ping, Taylor, Susan S.Language:
english
Journal:
Proceedings of the National Academy of Sciences
DOI:
10.1073/pnas.1906036116
Date:
July, 2019
File:
PDF, 1.85 MB
english, 2019