Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates
Staben, Leanna R., Chen, Jinhua, Cruz-Chuh, Josefa dela, Del Rosario, Geoffrey, Go, Mary Ann, Guo, Jun, Khojasteh, Siamak Cyrus, Kozak, Katherine R., Li, Guangmin, Ng, Carl, Lewis Phillips, Gail, PillJournal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.0c00691
Date:
July, 2020
File:
PDF, 1.70 MB
2020
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