Discovery of a Potent and Selective PI3Kδ Inhibitor ( S )-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4 H -quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
Shukla, Manojkumar R., Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J., Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, BhaJournal:
Journal of Medicinal Chemistry
DOI:
10.1021/acs.jmedchem.0c01264
Date:
December, 2020
File:
PDF, 3.20 MB
2020