Volume 23; Issue 3

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Investigational New Drugs
Volume 23; Issue 3

Investigational New Drugs

Volume 23; Issue 3

1

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug

Carmela Fimognari, Luca Sangiorgi, Silvia Capponcelli, Michael Nüsse, Silvia Fontanesi, Fausto Berti, Silvia Soddu, Giorgio Cantelli-Forti, Patrizia Hrelia

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 738 KB

english, 2005

2

Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell lines

Frank Mayer, Sandra Mueller, Elke Malenke, M. Kuczyk, Jörg T. Hartmann, Carsten Bokemeyer

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 891 KB

english, 2005

3

Cryptophycins-309, 249 and other cryptophycin analogs: Preclinical efficacy studies with mouse and human tumors

Jian Liang, Richard E. Moore, Eric D. Moher, John E. Munroe, Rima S. Al-awar, David A. Hay, David L. Varie, Tony Y. Zhang, James A. Aikins, Michael J. Martinelli, Chuan Shih, James E. Ray, Lowell L. G

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 206 KB

english, 2005

4

Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam

Charlotte van Kesteren, Anthe S. Zandvliet, Mats O. Karlsson, Ron A. A. Mathôt, Cornelis J. A. Punt, Jean-Pierre Armand, Eric Raymond, Alwin D. R. Huitema, Christian Dittrich, Herlinde Dumez, Henri H.

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 1001 KB

english, 2005

5

Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy

Dean Lim, Robert J. Morgan, Steven Akman, Kim Margolin, Brian I. Carr, Lucille Leong, Oluwole Odujinrin, James H. Doroshow

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 102 KB

english, 2005

6

A phase I trial of irinotecan (CPT-11) with amifostine in patients with metastatic colorectal cancer

Heather Wakelee, George A. Fisher

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 74 KB

english, 2005

7

Weekly irinotecan plus UFT and leucovorin as first-line chemotherapy of patients with advanced colorectal cancer

M. Méndez, P. G. Alfonso, E. Pujol, E. González, C. Castañon, P. Cerezuela, Y. López-Mateos, J. J. Cruz

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 315 KB

english, 2005

8

Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma

Michael J. Millward, Anthony Joshua, Rick Kefford, Steinar Aamdal, Damien Thomson, Peter Hersey, Guy Toner, Kevin Lynch

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 100 KB

english, 2005

9

Phase II trial of dolastatin-10 in patients with advanced breast cancer

Edith A. Perez, David W. Hillman, Paul A. Fishkin, James E. Krook, Winston W. Tan, Phillip A. Kuriakose, Steven R. Alberts, Shaker R. Dakhil

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 260 KB

english, 2005

10

Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer

Johan Vansteenkiste, Jean-Luc Canon, Henrik Riska, Robert Pirker, Patrick Peterson, William John, Pekka Mali, Michael Lahn

Journal:

Investigational New Drugs

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005