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Volume 29; Issue 6
Main
Investigational New Drugs
Volume 29; Issue 6
Investigational New Drugs
Volume 29; Issue 6
1
Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium
Deborah A. Bradley
,
Stephanie Daignault
,
Charles J. Ryan
,
Robert S. DiPaola
,
David C. Smith
,
Eric Small
,
Mitchell E. Gross
,
Mark N. Stein
,
Alice Chen
,
Maha Hussain
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 206 KB
Your tags:
english, 2011
2
Oral enzastaurin in prostate cancer: A two-cohort phase II trial in patients with PSA progression in the non-metastatic castrate state and following docetaxel-based chemotherapy for castrate metastatic disease
Robert Dreicer
,
Jorge Garcia
,
Maha Hussain
,
Brian Rini
,
Nicholas Vogelzang
,
Sandy Srinivas
,
Bradley Somer
,
Yan D. Zhao
,
Marek Kania
,
Derek Raghavan
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 164 KB
Your tags:
english, 2011
3
Phase II study of sunitinib as second-line treatment for advanced gastric cancer
Yung-Jue Bang
,
Yoon-Koo Kang
,
Won K. Kang
,
Narikazu Boku
,
Hyun C. Chung
,
Jen-Shi Chen
,
Toshihiko Doi
,
Yan Sun
,
Lin Shen
,
Shukui Qin
,
Wai-Tong Ng
,
Jennifer M. Tursi
,
Maria J. Lechuga
,
Dongrui Ray Lu
,
A
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 210 KB
Your tags:
english, 2011
4
Activity of topotecan given intravenously for 5
Emilio Esteban Gonzalez
,
Noemi Villanueva
,
Joaquin Fra
,
Jose Pablo Berros
,
Paula Jimenez
,
María Luque
,
Isabel Muñiz
,
Pilar Blay
,
Yolanda Fernandez
,
José María Vieitez
,
Carolina Muriel
,
Miguel Sanmamed
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 111 KB
Your tags:
english, 2011
5
Preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma
Edwin Pun Hui
,
Vivian W. Y. Lui
,
Cesar S. C. Wong
,
Brigette B. Y. Ma
,
Cecilia P. Y. Lau
,
Crystal S. F. Cheung
,
Kakiu Ho
,
Suk-hang Cheng
,
Margaret H. L. Ng
,
Anthony T. C. Chan
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 615 KB
Your tags:
english, 2011
6
Combined anticancer effects of sphingosine kinase inhibitors and sorafenib
Vladimir Beljanski
,
Christian Knaak
,
Yan Zhuang
,
Charles D. Smith
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 412 KB
Your tags:
english, 2011
7
LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells
Raquel C. Maia
,
Flavia C. Vasconcelos
,
Thiago de Sá Bacelar
,
Eduardo J. Salustiano
,
Luis Felipe R. da Silva
,
Débora L. Pereira
,
Arthur Moellman-Coelho
,
Chaquip D. Netto
,
Alcides J. da Silva
,
Vivian M.
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 466 KB
Your tags:
english, 2011
8
Dequalinium induces apoptosis in peripheral blood mononuclear cells isolated from human chronic lymphocytic leukemia
Lucia Pajuelo
,
Eva Calviño
,
Jose Carlos Diez
,
Maria del Carmen Boyano-Adánez
,
Juana Gil
,
Pilar Sancho
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 500 KB
Your tags:
english, 2011
9
A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC)
Michael R. Harrison
,
Noah M. Hahn
,
Roberto Pili
,
William K. Oh
,
Hans Hammers
,
Christopher Sweeney
,
KyungMann Kim
,
Scott Perlman
,
Jamie Arnott
,
Carolyn Sidor
,
George Wilding
,
Glenn Liu
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 198 KB
Your tags:
english, 2011
10
Discrepancy between in vitro and in vivo antitumor effect of a new platinum(II) metallointercalator
Johnny Moretto
,
Bruno Chauffert
,
François Ghiringhelli
,
Janice R. Aldrich-Wright
,
Florence Bouyer
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 673 KB
Your tags:
english, 2011
11
Q39, a quinoxaline 1,4-Di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells
Qinjie Weng
,
Jun Zhang
,
Ji Cao
,
Qing Xia
,
Duoduo Wang
,
Yongzhou Hu
,
Rong Sheng
,
Honghai Wu
,
Difeng Zhu
,
Hong Zhu
,
Qiaojun He
,
Bo Yang
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 741 KB
Your tags:
english, 2011
12
Inhibition of mouse embryonic carcinoma cell growth by lidamycin through down-regulation of embryonic stem cell-like genes Oct4, Sox2 and Myc
Hong-Ying Zhen
,
Qi-Hua He
,
Yong-Zhan Zhen
,
Shu-Ling Wang
,
Yi-Nan Liu
,
Wei-Hua Wu
,
Xiao-Yan Zhang
,
Ai-Li Lu
,
Li Shen
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 739 KB
Your tags:
english, 2011
13
Efficacy of RAD001 (everolimus) against advanced gastric cancer with peritoneal dissemination
Fumiko Taguchi
,
Yasuo Kodera
,
Yasufumi Katanasaka
,
Kazuyoshi Yanagihara
,
Tomohide Tamura
,
Fumiaki Koizumi
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 404 KB
Your tags:
english, 2011
14
The synthetic heat shock protein 90 (Hsp90) inhibitor EC141 induces degradation of Bcr-Abl p190 protein and apoptosis of Ph-positive acute lymphoblastic leukemia cells
Wei-Gang Tong
,
Zeev Estrov
,
Yongtao Wang
,
Susan O’Brien
,
Stefan Faderl
,
David M. Harris
,
Quin Van Pham
,
Inbal Hazan-Halevy
,
Zhiming Liu
,
Patricia Koch
,
Hagop Kantarjian
,
Michael J. Keating
,
Alessandra
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 285 KB
Your tags:
english, 2011
15
Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines
Alessandro Zanella
,
Valentina Gandin
,
Marina Porchia
,
Fiorenzo Refosco
,
Francesco Tisato
,
Francesca Sorrentino
,
Guido Scutari
,
Maria Pia Rigobello
,
Cristina Marzano
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 666 KB
Your tags:
english, 2011
16
The histone deacetylase inhibitor panobinostat demonstrates marked synergy with conventional chemotherapeutic agents in human ovarian cancer cell lines
Daniel R. Budman
,
Julia Tai
,
Anthony Calabro
,
Veena John
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 150 KB
Your tags:
english, 2011
17
Anti-tumour effects of xanthone derivatives and the possible mechanisms of action
Quan-Guan Su
,
Yan Liu
,
Yu-Chen Cai
,
Yue-Li Sun
,
Bo Wang
,
Li-Jian Xian
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 634 KB
Your tags:
english, 2011
18
Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells
Vivian Wai Yan Lui
,
Cecilia Pik Yuk Lau
,
KaKiu Ho
,
Margaret Heung Ling Ng
,
Suk Hang Cheng
,
Sai-Wah Tsao
,
Chi Man Tsang
,
Kenny Ieng Kit Lei
,
Anthony TC Chan
,
Tony Shu Kam Mok
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 514 KB
Your tags:
english, 2011
19
Evaluation of new iodinated acridine derivatives for targeted radionuclide therapy of melanoma using125I, an Auger electron emitter
Maryline Gardette
,
Janine Papon
,
Mathilde Bonnet
,
Nicolas Desbois
,
Pierre Labarre
,
Ting-Dee Wu
,
Elisabeth Miot-Noirault
,
Jean-Claude Madelmont
,
Jean-Luc Guerquin-Kern
,
Jean-Michel Chezal
,
Nicole Moins
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 515 KB
Your tags:
english, 2011
20
A multicenter, phase II study of Bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma
Manish A. Shah
,
Derek G. Power
,
Hedy L. Kindler
,
Kyle D. Holen
,
Margaret M. Kemeny
,
David H. Ilson
,
Laura Tang
,
Marinela Capanu
,
John J. Wright
,
David P. Kelsen
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 145 KB
Your tags:
english, 2011
21
Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis
Federica Servida
,
Daniele Lecis
,
Cinzia Scavullo
,
Carmelo Drago
,
Pierfausto Seneci
,
Carmelo Carlo-Stella
,
Leonardo Manzoni
,
Elio Polli
,
Giorgio Lambertenghi Deliliers
,
Domenico Delia
,
Francesco Onida
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 506 KB
Your tags:
english, 2011
22
Influence of mild and moderate hepatic impairment on axitinib pharmacokinetics
Michael A. Tortorici
,
Melvin Toh
,
S. V. Rahavendran
,
Robert R. LaBadie
,
Christine W. Alvey
,
Thomas Marbury
,
Ernesto Fuentes
,
Matthew Green
,
Grace Ni
,
Brian Hee
,
Yazdi K. Pithavala
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 228 KB
Your tags:
english, 2011
23
A pilot phase II trial of all-transretinoic acid (Vesanoid) and paclitaxel (Taxol) in patients with recurrent or metastatic breast cancer
Margarette Bryan
,
E. Dianne Pulte
,
Kathleen C. Toomey
,
Lillian Pliner
,
Anna C. Pavlick
,
Tracie Saunders
,
Robert Wieder
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 116 KB
Your tags:
english, 2011
24
Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT
Christopher R. Garrett
,
Domenico Coppola
,
Robert M. Wenham
,
Christopher L. Cubitt
,
Anthony M. Neuger
,
Timothy J. Frost
,
Richard M. Lush
,
Daniel M. Sullivan
,
Jin Q. Cheng
,
Saïd M. Sebti
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 157 KB
Your tags:
english, 2011
25
A phase I study of topotecan and gemcitabine in advanced solid tumors
Derek S. Serna
,
Tanios Bekaii-Saab
,
Eric H. Kraut
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 105 KB
Your tags:
english, 2011
26
The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells
Jin-Jian Lu
,
Si-Meng Chen
,
Xiao-Wei Zhang
,
Jian Ding
,
Ling-Hua Meng
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 238 KB
Your tags:
english, 2011
27
Modulation of P-gp expression by lapatinib
Gráinne Dunne
,
Laura Breen
,
Denis M. Collins
,
Sandra Roche
,
Martin Clynes
,
Robert O’Connor
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 406 KB
Your tags:
english, 2011
28
Cytostatic activity of the duplex drug linking 2′-deoxy-5-fluorouridine (5FdU) with 3′-C-ethynylcytidine (ECyd) against gastric adenocarcinoma cell lines
Jürgen Weinreich
,
Sarah Schott
,
Ingmar Königsrainer
,
Derek Zieker
,
Alfred Königsrainer
,
Herbert Schott
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 258 KB
Your tags:
english, 2011
29
Cediranib in combination with various anticancer regimens: results of a phase I multi-cohort study
Patricia LoRusso
,
Anthony F. Shields
,
Shirish Gadgeel
,
Ulka Vaishampayan
,
Tina Guthrie
,
Thomas Puchalski
,
John Xu
,
Qi Liu
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 412 KB
Your tags:
english, 2011
30
Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer
Takashi Sasaki
,
Hiroyuki Isayama
,
Yousuke Nakai
,
Suguru Mizuno
,
Keisuke Yamamoto
,
Hiroshi Yagioka
,
Yoko Yashima
,
Kazumichi Kawakubo
,
Hirofumi Kogure
,
Osamu Togawa
,
Saburo Matsubara
,
Naoki Sasahira
,
Ke
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 141 KB
Your tags:
english, 2011
31
Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status
Francesca Buontempo
,
Tulin Ersahin
,
Silvia Missiroli
,
Serif Senturk
,
Daniela Etro
,
Mehmet Ozturk
,
Silvano Capitani
,
Rengul Cetin-Atalay
,
Maria Luca Neri
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 621 KB
Your tags:
english, 2011
32
Reactivation of tuberculosis during temsirolimus therapy
Romain Coriat
,
Olivier Mir
,
Stanislas Ropert
,
Pierre Loulergue
,
Bertrand Billemont
,
François Goldwasser
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 134 KB
Your tags:
english, 2011
33
Phase I study of weekly plitidepsin as 1-hour infusion combined with carboplatin in patients with advanced solid tumors or lymphomas
Ramón Salazar
,
Ruth Plummer
,
Ana Oaknin
,
Angela Robinson
,
Beatriz Pardo
,
Arturo Soto-Matos
,
Alejandro Yovine
,
Sergio Szyldergemajn
,
Alan Hilary Calvert
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 141 KB
Your tags:
english, 2011
34
Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C
Marina F. Vita
,
Nivedita Nagachar
,
Dimitrios Avramidis
,
Zahid M. Delwar
,
Mabel H. Cruz
,
Åke Siden
,
Kajsa M. Paulsson
,
Juan Sebastian Yakisich
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 372 KB
Your tags:
english, 2011
35
Nature and subjectivity of dose-limiting toxicities in contemporary phase 1 trials: comparison of cytotoxic versus non-cytotoxic drugs
Nicolas Penel
,
Antoine Adenis
,
Stéphanie Clisant
,
Jacques Bonneterre
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 107 KB
Your tags:
english, 2011
36
A phase I study of the vitamin D3analogue ILX23-7553 administered orally to patients with advanced solid tumors
Rajul K. Jain
,
Donald L. Trump
,
Merrill J. Egorin
,
Manuel Fernandez
,
Candace S. Johnson
,
Ramesh K. Ramanathan
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 124 KB
Your tags:
english, 2011
37
Cellular uptake and cytoplasm / DNA distribution of cisplatin and oxaliplatin and their liposomal formulation in human colorectal cancer cell HCT116
Thititip Tippayamontri
,
Rami Kotb
,
Benoit Paquette
,
Léon Sanche
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 290 KB
Your tags:
english, 2011
38
Sonodynamic and photodynamic mechanisms of action of the novel hypocrellin sonosensitizer, SL017: mitochondrial cell death is attenuated by 11, 12-epoxyeicosatrienoic acid
Haitham E. El-Sikhry
,
Gerald G. Miller
,
Madi R. Madiyalakan
,
John M. Seubert
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 439 KB
Your tags:
english, 2011
39
YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway
Chin-Chuan Hung
,
Horng-Huei Liou
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 400 KB
Your tags:
english, 2011
40
Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π
Wen-Ying Chen
,
Yu-An Hsieh
,
Ching-I Tsai
,
Ya-Fei Kang
,
Fang-Rong Chang
,
Yang-Chang Wu
,
Chin-Chung Wu
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 664 KB
Your tags:
english, 2011
41
A phase 1 study of BMS-275183, a novel oral analogue of paclitaxel given on a daily schedule to patients with advanced malignancies
Elisabeth I. Heath
,
Patricia LoRusso
,
Suresh S. Ramalingam
,
Ahmad Awada
,
Merrill J. Egorin
,
Tatiana Besse-Hamer
,
Fatima Cardoso
,
Manuel Valdivieso
,
Teresa Has
,
Leila Alland
,
Xiaofei Zhou
,
Chandra P. B
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 101 KB
Your tags:
english, 2011
42
VEGF pathway inhibition by anticancer agent sunitinib and susceptibility to atherosclerosis plaque disruption
Stanislas Ropert
,
Olivier Vignaux
,
Olivier Mir
,
François Goldwasser
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 150 KB
Your tags:
english, 2011
43
Erratum to: Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium
Deborah A. Bradley
,
Stephanie Daignault
,
Charles J. Ryan
,
Robert S. DiPaola
,
Kathleen A. Cooney
,
David C. Smith
,
Eric Small
,
Paul Mathew
,
Mitchell E. Gross
,
Mark N. Stein
,
Alice Chen
,
Kenneth J. Pient
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 49 KB
Your tags:
english, 2011
44
Bevacizumab-induced small bowel perforation in a patient with breast cancer without intraabdominal metastases
Edouard Lecarpentier
,
Lamia Ouaffi
,
Olivier Mir
,
Paul Berveiller
,
Melinda Maurel
,
Eric Pujade-Lauraine
,
Jean Luc Bouillot
,
Nicolas Veyrie
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 341 KB
Your tags:
english, 2011
45
In vivo and in vitro assessment of the action of SN 28049, a benzonaphthyridine derivative targeting topoisomerase II, on the murine Colon 38 carcinoma
Ying Yi Chen
,
Graeme J. Finlay
,
James A. Kirker
,
Elaine S. Marshall
,
Emma Richardson
,
Bruce C. Baguley
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 678 KB
Your tags:
english, 2011
46
Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma
Charline Gomo
,
Romain Coriat
,
Lionel Faivre
,
Olivier Mir
,
Stanislas Ropert
,
Bertrand Billemont
,
Alain Dauphin
,
Michel Tod
,
Francois Goldwasser
,
Benoit Blanchet
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 89 KB
Your tags:
english, 2011
47
Letter to the editor: “Phase II trial of S-1 monotherapy in elderly or frail patients with metastatic colorectal cancer”
M. J. Molina-Garrido
,
Carmen Guillén-Ponce
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 60 KB
Your tags:
english, 2011
48
Combination adjuvant chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin after liver transplantation for hepatocellular carcinoma: a preliminary open-label study
Qing Zhang
,
Hong Chen
,
Qin Li
,
Yunjin Zang
,
Xinguo Chen
,
Weilong Zou
,
Letian Wang
,
Zhong-yang Shen
Journal:
Investigational New Drugs
Year:
2011
Language:
english
File:
PDF, 217 KB
Your tags:
english, 2011
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