Volume 31; Issue 5

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Investigational New Drugs
Volume 31; Issue 5

Investigational New Drugs

Volume 31; Issue 5

1

Phase II clinical study of modified FOLFOX7 (intermittent oxaliplatin administration) plus bevacizumab in patients with unresectable metastatic colorectal cancer—CRAFT study

Tohru Tezuka, Chikuma Hamada, Hideyuki Ishida, Mitsuru Ooshiro, Hiroshi Matsuoka, Shingo Kawasaki, Hideyuki Mishima, Kotaro Maeda, Junichi Sakamoto, Keiji Koda…show all 10hide

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 425 KB

english, 2013

2

A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors

Ivan Diaz-Padilla, Hal Hirte, Amit M. Oza, Blaise A. Clarke, Brenda Cohen, Michael Reedjik, Tong Zhang, Suzanne Kamel-Reid, S. Percy Ivy, Sebastien J. Hotte, Albiruni A. R. Razak, Eric X. Chen, Irene

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 344 KB

english, 2013

3

Pemetrexed and carboplatin followed by pemetrexed maintenance therapy in chemo-naïve patients with advanced nonsquamous non-small-cell lung cancer

Isamu Okamoto, Keisuke Aoe, Terufumi Kato, Yukio Hosomi, Akira Yokoyama, Fumio Imamura, Katsuyuki Kiura, Tomonori Hirashima, Makoto Nishio, Naoyuki Nogami, Hiroaki Okamoto, Hideo Saka, Nobuyuki Yamamo

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 294 KB

english, 2013

4

Phase 1 study of sorafenib in combination with bortezomib in patients with advanced malignancies

Shaji K. Kumar, James Jett, Randolph Marks, Ronald Richardson, Fernando Quevedo, Timothy Moynihan, Gary Croghan, Svetomir N. Markovic, Keith C. Bible, Rui Qin, Angelina Tan, Julian Molina, Scott H. Ka

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 191 KB

english, 2013

5

Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer

Dings, Ruud P. M., Levine, Joseph I., Brown, Susan G., Astorgues-Xerri, Lucile, MacDonald, John R., Hoye, Thomas R., Raymond, Eric, Mayo, Kevin H.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 489 KB

english, 2013

6

A phase II study of combined VEGF inhibitor (bevacizumab+sorafenib) in patients with metastatic breast cancer: Hoosier Oncology Group Study BRE06-109

Mina, Lida A., Yu, Menggang, Johnson, Cynthia, Burkhardt, Cyndi, Miller, Kathy D., Zon, Robin

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 112 KB

english, 2013

7

Erratum to: Vascular disrupting effect of CKD-516: preclinical study using DCE-MRI

Kim, Kyung Won, Lee, Jeong Min, Jeon, Yong Sik, Lee, In Joon, Choi, YoonSeok, Park, Jisuk, Kiefer, Berthold, Kim, Chin, Han, Joon Koo, Choi, Byung Ihn

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 54 KB

english, 2013

8

Erratum to: Pemetrexed and carboplatin followed by pemetrexed maintenance therapy in chemo-naïve patients with advanced nonsquamous non-small-cell lung cancer

Okamoto, Isamu, Aoe, Keisuke, Kato, Terufumi, Hosomi, Yukio, Yokoyama, Akira, Imamura, Fumio, Kiura, Katsuyuki, Hirashima, Tomonori, Nishio, Makoto, Nogami, Naoyuki, Okamoto, Hiroaki, Saka, Hideo, Yam

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 61 KB

english, 2013

9

Role of IL-8 induced angiogenesis in uveal melanoma

Lattanzio, Laura, Tonissi, Federica, Torta, Ilaria, Gianello, Luca, Russi, Elvio, Milano, Gerard, Merlano, Marco, Lo Nigro, Cristiana

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 388 KB

english, 2013

10

Vascular disrupting effect of CKD-516: preclinical study using DCE-MRI

Kim, Kyung Won, Lee, Jeong Min, Jeon, Yong Sik, Lee, In Joon, Choi, YoonSeok, Park, Jisuk, Kiefer, Berthold, Kim, Chin, Han, Joon Koo, Choi, Byung Ihn

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 797 KB

english, 2013

11

Bcl-2 antagonists: a proof of concept for CLL therapy

Balakrishnan, Kumudha, Gandhi, Varsha

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 470 KB

english, 2013

12

Methylation and histone deacetylase inhibition in combination with platinum treatment in patients with advanced malignancies

Falchook, Gerald S., Fu, Siqing, Naing, Aung, Hong, David S., Hu, Wei, Moulder, Stacy, Wheler, Jennifer J., Sood, Anil K., Bustinza-Linares, Ernesto, Parkhurst, Kristin L., Kurzrock, Razelle

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 274 KB

english, 2013

13

Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells

Saiko, Philipp, Graser, Geraldine, Giessrigl, Benedikt, Steinmann, Marie-Thérèse, Schuster, Heike, Lackner, Andreas, Grusch, Michael, Krupitza, Georg, Jaeger, Walter, Somepalli, Venkateswarlu, Golakot

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 393 KB

english, 2013

14

Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA

Marchetti, Serena, Pluim, Dick, Eijndhoven, Monique, Tellingen, Olaf, Mazzanti, Roberto, Beijnen, Jos H., Schellens, Jan H. M.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 693 KB

english, 2013

15

Genotype-dependent cooperation of ionizing radiation with BRAF inhibition in BRAF V600E-mutated carcinomas

Dasgupta, Tina, Haas-Kogan, Daphne A., Yang, Xiaodong, Olow, Aleksandra, Yang, Daniel X., Gragg, Ashley, Orloff, Lisa A., Yom, Sue S.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 230 KB

english, 2013

16

Phase Ib trial of the Toll-like receptor 9 agonist IMO-2055 in combination with 5-fluorouracil, cisplatin, and cetuximab as first-line palliative treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck

Machiels, Jean-Pascal, Kaminsky, Marie-Christine, Keller, Ulrich, Brümmendorf, Tim H., Goddemeier, Thomas, Forssmann, Ulf, Delord, Jean-Pierre

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 333 KB

english, 2013

17

Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome

Gojo, Ivana, Perl, Alexander, Luger, Selina, Baer, Maria R., Norsworthy, Kelly J., Bauer, Kenneth S., Tidwell, Michael, Fleckinger, Stephanie, Carroll, Martin, Sausville, Edward A.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 303 KB

english, 2013

18

An open-label study of the safety and tolerability of pazopanib in combination with FOLFOX6 or CapeOx in patients with colorectal cancer

Brady, Joanne, Corrie, Pippa, Chau, Ian, Digumarti, Raghunadharao, Adams, Laurel M., Botbyl, Jeffrey, Laubscher, Kevin H., Midgley, Rachel S., Mallath, Mohandas

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 164 KB

english, 2013

19

Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors

Sessa, Cristiana, Conte, Gianluca, Christinat, Alexandre, Cresta, Sara, Perotti, Antonella, Gallerani, Elisa, Lardelli, Pilar, Kahatt, Carmen, Alfaro, Vicente, Iglesias, Jorge L., Fernández-Teruel, Ca

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 202 KB

english, 2013

20

Novel bourgeonal fragrance conjugates for the detection of prostate cancer

Sturzu, Alexander, Sheikh, Sumbla, Echner, Hartmut, Nägele, Thomas, Deeg, Martin, Schwentner, Christian, Horger, Marius, Ernemann, Ulrike, Heckl, Stefan

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 270 KB

english, 2013

21

In silico analysis of the amido phosphoribosyltransferase inhibition by PY873, PY899 and a derivative of isophthalic acid

Batool, Sidra, Nawaz, Muhammad Sulaman, Kamal, Mohammad A.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 679 KB

english, 2013

22

A Phase I Study of the combination of oxaliplatin/docetaxel and vandetanib for the treatment of advanced gastroesophageal cancer

Halmos, Balazs, Jia, Yuxia, Bokar, Joseph A., Fu, Pingfu, Adelstein, David J., Juergens, Rosalyn, Rodal, Mary Beth, Dowlati, Afshin

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 149 KB

english, 2013

23

Phase I study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies

Schenk, Erin, Hendrickson, Andrea E. Wahner, Northfelt, Donald, Toft, David O., Ames, Matthew M., Menefee, Michael, Satele, Daniel, Qin, Rui, Erlichman, Charles

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 144 KB

english, 2013

24

A phase I/II study of decitabine in combination with panitumumab in patients with wild-type (wt)KRASmetastatic colorectal cancer

Garrido-Laguna, I., McGregor, K. A., Wade, M., Weis, J., Gilcrease, W., Burr, L., Soldi, R., Jakubowski, L., Davidson, C., Morrell, G., Olpin, J. D., Boucher, K., Jones, D., Sharma, S.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 339 KB

english, 2013

25

Bronchoscopic findings for bevacizumab-related pulmonary hemorrhage in advanced non–small cell lung cancer

Okamoto, Kunio, Okamoto, Isamu, Miyazaki, Masaki, Tanaka, Kaoru, Kaneda, Hiroyasu, Nakagawa, Kazuhiko

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 202 KB

english, 2013

26

Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line

Funakoshi, Yohei, Mukohara, Toru, Tomioka, Hideo, Ekyalongo, Roudy Chiminch, Kataoka, Yu, Inui, Yumiko, Kawamori, Yuriko, Toyoda, Masanori, Kiyota, Naomi, Fujiwara, Yutaka, Minami, Hironobu

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 796 KB

english, 2013

27

Efficacy, safety, and pharmacokinetics of imatinib dose escalation to 800

Yoo, Changhoon, Ryu, Min-Hee, Ryoo, Baek-Yeol, Beck, Mo Youl, Kang, Yoon-Koo

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 259 KB

english, 2013

28

Effect of small angiokinase inhibitor nintedanib (BIBF 1120) on QT interval in patients with previously untreated, advanced renal cell cancer in an open-label, phase II study

Eisen, Tim, Shparyk, Yaroslav, Macleod, Nicholas, Jones, Robert, Wallenstein, Gudrun, Temple, Graham, Khder, Yasser, Dallinger, Claudia, Studeny, Matus, Loembe, Arsene-Bienvenu, Bondarenko, Igor

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 266 KB

english, 2013

29

The addition of erlotinib to gemcitabine and cisplatin does not appear to improve median survival in metastatic pancreatic cancer

Khalil, Mohamed A., Qiao, Wei, Carlson, Peter, George, Binsah, Javle, Milind, Overman, Michael, Varadhachary, Gauri, Wolff, Robert A., Abbruzzese, James L., Fogelman, David R.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 246 KB

english, 2013

30

Bortezomib overcomes MGMT-related resistance of glioblastoma cell lines to temozolomide in a schedule-dependent manner

Vlachostergios, Panagiotis J., Hatzidaki, Eleana, Befani, Christina D., Liakos, Panagiotis, Papandreou, Christos N.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 528 KB

english, 2013

31

A multicenter phase II trial of gemcitabine and candesartan combination therapy in patients with advanced pancreatic cancer: GECA2

Nakai, Yousuke, Isayama, Hiroyuki, Ijichi, Hideaki, Sasaki, Takashi, Takahara, Naminatsu, Ito, Yukiko, Matsubara, Saburo, Uchino, Rie, Yagioka, Hiroshi, Arizumi, Toshihiko, Hamada, Tsuyoshi, Miyabayas

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 174 KB

english, 2013

32

A randomized, multi-center, open-label, phase II study of once-per-cycle DA-3031, a biosimilar pegylated G-CSF, compared with daily filgrastim in patients receiving TAC chemotherapy for early-stage breast cancer

Park, K. H., Sohn, J. H., Lee, S., Park, J. H., Kang, S. Y., Kim, H. Y., Park, I. H., Park, Y. H., Im, Y. H., Lee, H. J., Hong, D. S., Park, S., Shin, S. H., Kwon, H. C., Seo, J. H.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 162 KB

english, 2013

33

A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance)

Gupta, Pankaj, Mulkey, Flora, Hasserjian, Robert P., Sanford, Ben L., Vij, Ravi, Hurd, David D., Odenike, Olatoyosi M., Bloomfield, Clara D., Owzar, Kouros, Stone, Richard M., Larson, Richard A.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 204 KB

english, 2013

34

Sunitinib malate in previously untreated, nonsquamous, non-small cell lung cancer patients over the age of 70

Reynolds, Craig, Spira, Alexander I., Gluck, Larry, Mueller, Suzanne E., Zhan, Feng, Boehm, Kristi A., Asmar, Lina

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 363 KB

english, 2013

35

Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: results of the Phase II CINATRA trial

Moorcraft, S. Y., Chau, I., Peckitt, C., Cunningham, D., Rao, S., Yim, K. L., Walther, A., Jackson, C. G. C. A., Stamp, G., Webb, J., Smith, G., Gillbanks, A., Swanton, C.

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 175 KB

english, 2013

36

Cediranib in combination with fulvestrant in hormone-sensitive metastatic breast cancer: a randomized Phase II study

Hyams, David M., Chan, Arlene, Oliveira, Celia, Snyder, Raymond, Vinholes, Jeferson, Audeh, M. William, Alencar, Victor M., Lombard, Janine, Mookerjee, Bijoyesh, Xu, John, Brown, Kathryn, Klein, Paula

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 271 KB

english, 2013

37

Phase II study of sunitinib in Japanese patients with unresectable or metastatic, well-differentiated pancreatic neuroendocrine tumor

Ito, Tetsuhide, Okusaka, Takuji, Nishida, Toshirou, Yamao, Kenji, Igarashi, Hisato, Morizane, Chigusa, Kondo, Shunsuke, Mizuno, Nobumasa, Hara, Kazuo, Sawaki, Akira, Hashigaki, Satoshi, Kimura, Nobuyu

Journal:

Investigational New Drugs

Year:

2013

Language:

english

File:

PDF, 378 KB

english, 2013