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Volume 32; Issue 2
Main
Investigational New Drugs
Volume 32; Issue 2
Investigational New Drugs
Volume 32; Issue 2
1
Phase I clinical trial of lenalidomide in combination with sorafenib in patients with advanced cancer
Prasanth Ganesan, Sarina Piha-Paul, Aung Naing, Gerald Falchook, Jennifer Wheler, Siqing Fu, David S. Hong, Razelle Kurzrock, Filip Janku, Shell Laday, Agop Y. Bedikian, Merrill Kies, Robert A. Wolff,
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 258 KB
Your tags:
english, 2014
2
A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer
William R. Schelman, Tabraiz A. Mohammed, Anne M. Traynor, Jill M. Kolesar, Rebecca M. Marnocha, Jens Eickhoff, Michael Keppen, Dona B. Alberti, George Wilding, Naoko Takebe, Glenn Liu…show all 11hide
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 170 KB
Your tags:
english, 2014
3
Icrucumab, a fully human monoclonal antibody against the vascular endothelial growth factor receptor-1, in the treatment of patients with advanced solid malignancies: a Phase 1 study
Patricia M. LoRusso, Smitha Krishnamurthi, Hagop Youssoufian, Nancy Hall, Floyd Fox, Aruna Dontabhaktuni, Dmitri Grebennik, Scot Remick
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 176 KB
Your tags:
english, 2014
4
Synthesis and in vitro characterization of ionone-based compounds as dual inhibitors of the androgen receptor and NF-κB
Liu, Weiguo
,
Zhou, Jinming
,
Geng, Guoyan
,
Lin, Rongtuan
,
Wu, Jian Hui
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 454 KB
Your tags:
english, 2014
5
A prospective multicenter phase II study of sunitinib in patients with advanced aggressive fibromatosis
Jo, Jae-Cheol
,
Hong, Yong Sang
,
Kim, Kyu-Pyo
,
Lee, Jae-Lyun
,
Lee, Jeeyun
,
Park, Young Suk
,
Kim, Sun Young
,
Ryu, Jin-Sook
,
Lee, Jong-Seok
,
Kim, Tae Won
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 393 KB
Your tags:
english, 2014
6
Phase II trial of Sorafenib in conjunction with chemotherapy and as maintenance therapy in extensive-stage small cell lung cancer
Sharma, Neelesh
,
Pennell, Nathan
,
Nickolich, Myles
,
Halmos, Balazs
,
Ma, Patrick
,
Mekhail, Tarek
,
Fu, Pingfu
,
Dowlati, Afshin
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 194 KB
Your tags:
english, 2014
7
Low skeletal muscle is associated with toxicity in patients included in phase I trials
Cousin, Sophie
,
Hollebecque, A.
,
Koscielny, S.
,
Mir, O.
,
Varga, A.
,
Baracos, V. E.
,
Soria, J. C.
,
Antoun, S.
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 209 KB
Your tags:
english, 2014
8
A phase II trial of a selective c-Met inhibitor tivantinib (ARQ 197) monotherapy as a second- or third-line therapy in the patients with metastatic gastric cancer
Kang, Yoon-Koo
,
Muro, Kei
,
Ryu, Min-Hee
,
Yasui, Hirofumi
,
Nishina, Tomohiro
,
Ryoo, Baek-Yeol
,
Kamiya, Yukimasa
,
Akinaga, Shiro
,
Boku, Narikazu
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 234 KB
Your tags:
english, 2014
9
Safety, tolerability, and pharmacokinetics of the novel αv-integrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses
Uhl, Wolfgang
,
Zühlsdorf, Michael
,
Koernicke, Thomas
,
Forssmann, Ulf
,
Kovar, Andreas
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 367 KB
Your tags:
english, 2014
10
Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer
Strickler, John H.
,
McCall, Shannon
,
Nixon, Andrew B.
,
Brady, John C.
,
Pang, Herbert
,
Rushing, Christel
,
Cohn, Allen
,
Starodub, Alexander
,
Arrowood, Christy
,
Haley, Sherri
,
Meadows, Kellen L.
,
Morse,
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 461 KB
Your tags:
english, 2014
11
Erratum to: Regorafenib in Japanese patients with solid tumors: phase I study of safety, efficacy, and pharmacokinetics
Sunakawa, Yu
,
Furuse, Junji
,
Okusaka, Takuji
,
Ikeda, Masafumi
,
Nagashima, Fumio
,
Ueno, Hideki
,
Mitsunaga, Shuichi
,
Hashizume, Kensei
,
Ito, Yuichiro
,
Sasaki, Yasutsuna
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 62 KB
Your tags:
english, 2014
12
Reduced folate carrier (RFC) as a predictive marker for response to pemetrexed in advanced non-small cell lung cancer (NSCLC)
Alvarez-Fernandez, Carlos
,
Perez-Arnillas, Quionia
,
Ruiz-Echeverria, Lucrecia
,
Rodriguez-Rubi, David
,
Sanchez-Lorenzo, Luisa
,
Li-Torres, Walter
,
Izquierdo-Manuel, Marta
,
Berros, Jose P.
,
Luque-Cabal,
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 145 KB
Your tags:
english, 2014
13
Phase I and pharmacodynamic study of vorinostat combined with capecitabine and cisplatin as first-line chemotherapy in advanced gastric cancer
Yoo, Changhoon
,
Ryu, Min-Hee
,
Na, Young-Soon
,
Ryoo, Baek-Yeol
,
Lee, Chae-Won
,
Maeng, Jeheon
,
Kim, Se-Yeon
,
Koo, Dong Hoe
,
Park, Inkeun
,
Kang, Yoon-Koo
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 197 KB
Your tags:
english, 2014
14
A phase I trial of bortezomib in combination with epirubicin, carboplatin and capecitabine (ECarboX) in advanced oesophagogastric adenocarcinoma
Turkington, R. C.
,
Purcell, C.
,
James, C. R.
,
Millar, J.
,
Napier, E.
,
Law, D.
,
Gallagher, R.
,
Morris, M.
,
Wilson, R. H.
,
Eatock, M. M.
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 231 KB
Your tags:
english, 2014
15
Phase I study of sunitinib plus S-1 and cisplatin in Japanese patients with advanced or metastatic gastric cancer
Boku, Narikazu
,
Muro, Kei
,
Machida, Nozomu
,
Hashigaki, Satoshi
,
Kimura, Nobuyuki
,
Suzuki, Mie
,
Lechuga, Mariajose
,
Miyata, Yoshinori
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 353 KB
Your tags:
english, 2014
16
A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
Richter, Suzanne
,
Bedard, Philippe L.
,
Chen, Eric Xueyu
,
Clarke, Blaise A.
,
Tran, Ben
,
Hotte, Sebastien J.
,
Stathis, Anastasios
,
Hirte, Hal W.
,
Razak, Albiruni R. A.
,
Reedijk, Michael
,
Chen, Zhuo
,
Coh
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 439 KB
Your tags:
english, 2014
17
HLA-restricted NY-ESO-1 peptide immunotherapy for metastatic castration resistant prostate cancer
Sonpavde, Guru
,
Wang, Mingjun
,
Peterson, Leif E.
,
Wang, Helen Y.
,
Joe, Teresa
,
Mims, Martha P.
,
Kadmon, Dov
,
Ittmann, Michael M.
,
Wheeler, Thomas M.
,
Gee, Adrian P.
,
Wang, Rong-Fu
,
Hayes, Teresa G.
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 250 KB
Your tags:
english, 2014
18
Phase I trial of sorafenib in combination with ifosfamide in patients with advanced sarcoma: a Spanish group for research on sarcomas (GEIS) study
Martín-Liberal, J.
,
López-Pousa, A.
,
Broto, J. Martín
,
Cubedo, R.
,
Gallego, O.
,
Brendel, E.
,
Tirado, O. M.
,
Muro, X. García
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 293 KB
Your tags:
english, 2014
19
A Phase I study of intermittently dosed vorinostat in combination with bortezomib in patients with advanced solid tumors
Deming, Dustin A.
,
Ninan, Jacob
,
Bailey, Howard H.
,
Kolesar, Jill M.
,
Eickhoff, Jens
,
Reid, Joel M.
,
Ames, Matthew M.
,
McGovern, Renee M.
,
Alberti, Dona
,
Marnocha, Rebecca
,
Espinoza-Delgado, Igor
,
Wri
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 151 KB
Your tags:
english, 2014
20
Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor
King, Constance
,
Diaz, Henry
,
Barnard, Darlene
,
Barda, David
,
Clawson, David
,
Blosser, Wayne
,
Cox, Karen
,
Guo, Sherry
,
Marshall, Mark
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 969 KB
Your tags:
english, 2014
21
Weekly EZN-2208 (PEGylated SN-38) in combination with bevacizumab in patients with refractory solid tumors
Jeong, Woondong
,
Park, Sook Ryun
,
Rapisarda, Annamaria
,
Fer, Nicole
,
Kinders, Robert J.
,
Chen, Alice
,
Melillo, Giovanni
,
Turkbey, Baris
,
Steinberg, Seth M.
,
Choyke, Peter
,
Doroshow, James H.
,
Kummar,
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 274 KB
Your tags:
english, 2014
22
Sorafenib plus dacarbazine in solid tumors: a phase I study with dynamic contrast-enhanced ultrasonography and genomic analysis of sequential tumor biopsy samples
Lazar, Vladimir
,
Lassau, Nathalie
,
Meurice, Guillaume
,
Loriot, Yohann
,
Peña, Carol
,
Massard, Christophe
,
Robert, Caroline
,
Robert, Thomas
,
Berre, Marie-Aude
,
Baere, Thierry
,
Dessen, Philippe
,
Soria, J
Journal:
Investigational New Drugs
Year:
2014
Language:
english
File:
PDF, 670 KB
Your tags:
english, 2014
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