Volume 33; Issue 2

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Investigational New Drugs
Volume 33; Issue 2

Investigational New Drugs

Volume 33; Issue 2

1

The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations

Mathias, Trevor J., Natarajan, Karthika, Shukla, Suneet, Doshi, Kshama A., Singh, Zeba N., Ambudkar, Suresh V., Baer, Maria R.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.16 MB

english, 2015

2

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

Alumkal, Joshi J., Slottke, Rachel, Schwartzman, Jacob, Cherala, Ganesh, Munar, Myrna, Graff, Julie N., Beer, Tomasz M., Ryan, Christopher W., Koop, Dennis R., Gibbs, Angela, Gao, Lina, Flamiatos, Jas

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 375 KB

english, 2015

3

Aptamers as a novel tool for diagnostics and therapy

Kadioglu, Onat, Malczyk, Anna Helena, Greten, Henry Johannes, Efferth, Thomas

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 366 KB

english, 2015

4

Chemotherapy in vivo against M109 murine lung carcinoma with cytochalasin B by localized, systemic, and liposomal administration

Trendowski, Matthew, Mitchell, Joan M., Corsette, Christine M., Acquafondata, Christopher, Fondy, Thomas P.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.43 MB

english, 2015

5

Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma

Yau, Thomas, Cheng, Paul N., Chan, Pierre, Chen, Li, Yuen, Jimmy, Pang, Roberta, Fan, Sheung Tat, Wheatley, Denys N., Poon, Ronnie T.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 301 KB

english, 2015

6

Axitinib plasma pharmacokinetics and ethnic differences

Chen, Ying, Suzuki, Akiyuki, Tortorici, Michael A., Garrett, May, LaBadie, Robert R., Umeyama, Yoshiko, Pithavala, Yazdi K.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 408 KB

english, 2015

7

PBI-05204, a supercritical CO2extract ofNerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway

Pan, Yong, Rhea, Patrea, Tan, Lin, Cartwright, Carrie, Lee, Ho-Jeong, Ravoori, Murali K., Addington, Crandell, Gagea, Mihai, Kundra, Vikas, Kim, Sun-Jin, Newman, Robert A., Yang, Peiying

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

8

Infected complex renal cysts during crizotinib therapy in a patient with non–small cell lung cancer positive forALKrearrangement

Yoneshima, Yasuto, Okamoto, Isamu, Arimura-Omori, Masako, Kimura, Shinichi, Hidaka-Fujimoto, Noriko, Iwama, Eiji, Harada, Taishi, Takayama, Koichi, Nakanishi, Yoichi

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 326 KB

english, 2015

9

A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors

Peethambaram, P. P., Hartmann, L. C., Jonker, D. J., de Jonge, M., Plummer, E. R., Martin, L., Konner, J., Marshall, J., Goss, G. D., Teslenko, V., Clemens, P. L., Cohen, L. J., Ahlers, C. M., Alland,

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 545 KB

english, 2015

10

Phase 1/2 study of orteronel (TAK-700), an investigational 17,20-lyase inhibitor, with docetaxel–prednisone in metastatic castration-resistant prostate cancer

Petrylak, Daniel P., Gandhi, Jitendra G., Clark, William R., Heath, Elisabeth, Lin, Jianqing, Oh, William K., Agus, David B., Carthon, Bradley, Moran, Susan, Kong, Ning, Suri, Ajit, Bargfrede, Michael

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 346 KB

english, 2015

11

A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia

Odenike, Olatoyosi, Halpern, Anna, Godley, Lucy A., Madzo, Jozef, Karrison, Theodore, Green, Margaret, Fulton, Noreen, Mattison, Ryan J., Yee, Karen. W. L., Bennett, Meghan, Koval, Gregory, Malnassy,

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 275 KB

english, 2015

12

Pharmacokinetic study of aldoxorubicin in patients with solid tumors

Mita, Monica M., Natale, Ronald B., Wolin, Edward M., Laabs, Brenda, Dinh, Hillary, Wieland, Scott, Levitt, Daniel J., Mita, Alain C.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 463 KB

english, 2015

13

Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer

Rodón, Jordi, Carducci, Michael, Sepulveda-Sánchez, Juan M., Azaro, Analía, Calvo, Emiliano, Seoane, Joan, Braña, Irene, Sicart, Elisabet, Gueorguieva, Ivelina, Cleverly, Ann, Pillay, N. Sokalingum, D

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

14

Phase-I dose finding and pharmacokinetic study of the novel hydrophilic camptothecin ST-1968 (namitecan) in patients with solid tumors

Joerger, M., Hess, D., Delmonte, A., Gallerani, E., Barbieri, P., Pace, S., Sessa, C.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

15

A phase I study of farletuzumab, a humanized anti-folate receptor α monoclonal antibody, in patients with solid tumors

Sasaki, Yasutsuna, Miwa, Keisuke, Yamashita, Keishi, Sunakawa, Yu, Shimada, Ken, Ishida, Hiroo, Hasegawa, Kosei, Fujiwara, Keiichi, Kodaira, Makoto, Fujiwara, Yasuhiro, Namiki, Masayuki, Matsuda, Mina

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 612 KB

english, 2015

16

Everolimus and pasireotide for advanced and metastatic hepatocellular carcinoma

Sanoff, Hanna K., Kim, Richard, Ivanova, Anastasia, Alistar, Angela, McRee, Autumn J., O’Neil, Bert H.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 180 KB

english, 2015

17

Phase II trial of combination therapy of gemcitabine plus anti-angiogenic vaccination of elpamotide in patients with advanced or recurrent biliary tract cancer

Matsuyama, Masato, Ishii, H., Furuse, J., Ohkawa, S., Maguchi, H., Mizuno, N., Yamaguchi, T., Ioka, T., Ajiki, T., Ikeda, M., Hakamada, K., Yamamoto, M., Yamaue, H., Eguchi, K., Ichikawa, W., Miyazaki

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 281 KB

english, 2015

18

Treatment effect of buparlisib, cetuximab and irradiation in wild-type orPI3KCA-mutated head and neck cancer cell lines

Lattanzio, Laura, Tonissi, Federica, Monteverde, Martino, Vivenza, Daniela, Russi, Elvio, Milano, Gérard, Merlano, Marco, Lo Nigro, Cristiana

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.26 MB

english, 2015

19

Phase 1 study of the oral histone deacetylase inhibitor abexinostat in patients with Hodgkin lymphoma, non-Hodgkin lymphoma, or chronic lymphocytic leukaemia

Morschhauser, Franck, Terriou, Louis, Coiffier, Bertrand, Bachy, Emmanuel, Varga, Andrea, Kloos, Ioana, Lelièvre, Hélène, Sarry, Anne-Laure, Depil, Stéphane, Ribrag, Vincent

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 772 KB

english, 2015

20

Chemotherapy with cytochalasin congeners in vitro and in vivo against murine models

Trendowski, Matthew, Mitchell, Joan M., Corsette, Christine M., Acquafondata, Christopher, Fondy, Thomas P.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 2.01 MB

english, 2015

21

Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors

Dickson, Mark A., Gordon, Michael S., Edelman, Gerald, Bendell, Johanna C., Kudchadkar, Ragini R., LoRusso, Patricia M., Johnston, Stuart H., Clary, Douglas O., Schwartz, Gary K.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 609 KB

english, 2015

22

Phase I study of amatuximab, a novel monoclonal antibody to mesothelin, in Japanese patients with advanced solid tumors

Fujisaka, Yasuhito, Kurata, Takayasu, Tanaka, Kaoru, Kudo, Toshihiro, Okamoto, Kunio, Tsurutani, Junji, Kaneda, Hiroyasu, Okamoto, Isamu, Namiki, Masayuki, Kitamura, Chifumi, Nakagawa, Kazuhiko

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 537 KB

english, 2015

23

Phase I study of the novel Cdc2/CDK1 and AKT inhibitor terameprocol in patients with advanced leukemias

Tibes, R., McDonagh, K. T., Lekakis, L., Bogenberger, J. M., Kim, S., Frazer, N., Mohrland, S., Bassett, D., Garcia, R., Schroeder, K., Shanmugam, V., Carpten, J., Hagelstrom, R. T., Beaudry, C., Von

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 170 KB

english, 2015

24

A phase 1 dose escalation study of BI 831266, an inhibitor of Aurora kinase B, in patients with advanced solid tumors

Dittrich, Christian, Fridrik, Michael A., Koenigsberg, Robert, Lee, Chooi, Goeldner, Rainer-Georg, Hilbert, James, Greil, Richard

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 2.44 MB

english, 2015

25

Phase 1b study of the oral gemcitabine ‘Pro-drug’ LY2334737 in combination with capecitabine in patients with advanced solid tumors

Infante, Jeffrey R., Benhadji, Karim A., Dy, Grace K., Fetterly, Gerald, Ma, Wen Wee, Bendell, Johanna, Callies, Sophie, Adjei, Alex A.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 825 KB

english, 2015

26

First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors

LoRusso, Patricia M., Goncalves, Priscila H., Casetta, Lindsay, Carter, Judith A., Litwiler, Kevin, Roseberry, Dale, Rush, Selena, Schreiber, Jennifer, Simmons, Heidi M., Ptaszynski, Mieke, Sausville,

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 607 KB

english, 2015

27

Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMC-A12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors

Higano, C. S., Berlin, J., Gordon, M., LoRusso, P., Tang, S., Dontabhaktuni, A., Schwartz, J. D., Cosaert, J., Mehnert, J. M.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 457 KB

english, 2015

28

A phase 1 study of the sachet formulation of the oral dual PI3K/mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors

Bendell, Johanna C., Kurkjian, Carla, Infante, Jeffrey R., Bauer, Todd M., Burris, Howard A., Greco, F. Anthony, Shih, Kent C., Thompson, Dana S., Lane, Cassie M., Finney, Lindsey H., Jones, Suzanne F

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.07 MB

english, 2015

29

Acknowledgement of Reviewers 2013

Journal:

Investigational New Drugs

Year:

2015

File:

PDF, 69 KB

2015

30

Acknowledgement of Reviewers 2014

Journal:

Investigational New Drugs

Year:

2015

File:

PDF, 77 KB

2015