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Volume 33; Issue 2
Main
Investigational New Drugs
Volume 33; Issue 2
Investigational New Drugs
Volume 33; Issue 2
1
The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations
Mathias, Trevor J.
,
Natarajan, Karthika
,
Shukla, Suneet
,
Doshi, Kshama A.
,
Singh, Zeba N.
,
Ambudkar, Suresh V.
,
Baer, Maria R.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.16 MB
Your tags:
english, 2015
2
A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer
Alumkal, Joshi J.
,
Slottke, Rachel
,
Schwartzman, Jacob
,
Cherala, Ganesh
,
Munar, Myrna
,
Graff, Julie N.
,
Beer, Tomasz M.
,
Ryan, Christopher W.
,
Koop, Dennis R.
,
Gibbs, Angela
,
Gao, Lina
,
Flamiatos, Jas
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 375 KB
Your tags:
english, 2015
3
Aptamers as a novel tool for diagnostics and therapy
Kadioglu, Onat
,
Malczyk, Anna Helena
,
Greten, Henry Johannes
,
Efferth, Thomas
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 366 KB
Your tags:
english, 2015
4
Chemotherapy in vivo against M109 murine lung carcinoma with cytochalasin B by localized, systemic, and liposomal administration
Trendowski, Matthew
,
Mitchell, Joan M.
,
Corsette, Christine M.
,
Acquafondata, Christopher
,
Fondy, Thomas P.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.43 MB
Your tags:
english, 2015
5
Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma
Yau, Thomas
,
Cheng, Paul N.
,
Chan, Pierre
,
Chen, Li
,
Yuen, Jimmy
,
Pang, Roberta
,
Fan, Sheung Tat
,
Wheatley, Denys N.
,
Poon, Ronnie T.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 301 KB
Your tags:
english, 2015
6
Axitinib plasma pharmacokinetics and ethnic differences
Chen, Ying
,
Suzuki, Akiyuki
,
Tortorici, Michael A.
,
Garrett, May
,
LaBadie, Robert R.
,
Umeyama, Yoshiko
,
Pithavala, Yazdi K.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 408 KB
Your tags:
english, 2015
7
PBI-05204, a supercritical CO2extract ofNerium oleander, inhibits growth of human pancreatic cancer via targeting the PI3K/mTOR pathway
Pan, Yong
,
Rhea, Patrea
,
Tan, Lin
,
Cartwright, Carrie
,
Lee, Ho-Jeong
,
Ravoori, Murali K.
,
Addington, Crandell
,
Gagea, Mihai
,
Kundra, Vikas
,
Kim, Sun-Jin
,
Newman, Robert A.
,
Yang, Peiying
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 2.67 MB
Your tags:
english, 2015
8
Infected complex renal cysts during crizotinib therapy in a patient with non–small cell lung cancer positive forALKrearrangement
Yoneshima, Yasuto
,
Okamoto, Isamu
,
Arimura-Omori, Masako
,
Kimura, Shinichi
,
Hidaka-Fujimoto, Noriko
,
Iwama, Eiji
,
Harada, Taishi
,
Takayama, Koichi
,
Nakanishi, Yoichi
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 326 KB
Your tags:
english, 2015
9
A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors
Peethambaram, P. P.
,
Hartmann, L. C.
,
Jonker, D. J.
,
de Jonge, M.
,
Plummer, E. R.
,
Martin, L.
,
Konner, J.
,
Marshall, J.
,
Goss, G. D.
,
Teslenko, V.
,
Clemens, P. L.
,
Cohen, L. J.
,
Ahlers, C. M.
,
Alland,
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 545 KB
Your tags:
english, 2015
10
Phase 1/2 study of orteronel (TAK-700), an investigational 17,20-lyase inhibitor, with docetaxel–prednisone in metastatic castration-resistant prostate cancer
Petrylak, Daniel P.
,
Gandhi, Jitendra G.
,
Clark, William R.
,
Heath, Elisabeth
,
Lin, Jianqing
,
Oh, William K.
,
Agus, David B.
,
Carthon, Bradley
,
Moran, Susan
,
Kong, Ning
,
Suri, Ajit
,
Bargfrede, Michael
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 346 KB
Your tags:
english, 2015
11
A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia
Odenike, Olatoyosi
,
Halpern, Anna
,
Godley, Lucy A.
,
Madzo, Jozef
,
Karrison, Theodore
,
Green, Margaret
,
Fulton, Noreen
,
Mattison, Ryan J.
,
Yee, Karen. W. L.
,
Bennett, Meghan
,
Koval, Gregory
,
Malnassy,
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 275 KB
Your tags:
english, 2015
12
Pharmacokinetic study of aldoxorubicin in patients with solid tumors
Mita, Monica M.
,
Natale, Ronald B.
,
Wolin, Edward M.
,
Laabs, Brenda
,
Dinh, Hillary
,
Wieland, Scott
,
Levitt, Daniel J.
,
Mita, Alain C.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 463 KB
Your tags:
english, 2015
13
Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer
Rodón, Jordi
,
Carducci, Michael
,
Sepulveda-Sánchez, Juan M.
,
Azaro, Analía
,
Calvo, Emiliano
,
Seoane, Joan
,
Braña, Irene
,
Sicart, Elisabet
,
Gueorguieva, Ivelina
,
Cleverly, Ann
,
Pillay, N. Sokalingum
,
D
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.90 MB
Your tags:
english, 2015
14
Phase-I dose finding and pharmacokinetic study of the novel hydrophilic camptothecin ST-1968 (namitecan) in patients with solid tumors
Joerger, M.
,
Hess, D.
,
Delmonte, A.
,
Gallerani, E.
,
Barbieri, P.
,
Pace, S.
,
Sessa, C.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.25 MB
Your tags:
english, 2015
15
A phase I study of farletuzumab, a humanized anti-folate receptor α monoclonal antibody, in patients with solid tumors
Sasaki, Yasutsuna
,
Miwa, Keisuke
,
Yamashita, Keishi
,
Sunakawa, Yu
,
Shimada, Ken
,
Ishida, Hiroo
,
Hasegawa, Kosei
,
Fujiwara, Keiichi
,
Kodaira, Makoto
,
Fujiwara, Yasuhiro
,
Namiki, Masayuki
,
Matsuda, Mina
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 612 KB
Your tags:
english, 2015
16
Everolimus and pasireotide for advanced and metastatic hepatocellular carcinoma
Sanoff, Hanna K.
,
Kim, Richard
,
Ivanova, Anastasia
,
Alistar, Angela
,
McRee, Autumn J.
,
O’Neil, Bert H.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 180 KB
Your tags:
english, 2015
17
Phase II trial of combination therapy of gemcitabine plus anti-angiogenic vaccination of elpamotide in patients with advanced or recurrent biliary tract cancer
Matsuyama, Masato
,
Ishii, H.
,
Furuse, J.
,
Ohkawa, S.
,
Maguchi, H.
,
Mizuno, N.
,
Yamaguchi, T.
,
Ioka, T.
,
Ajiki, T.
,
Ikeda, M.
,
Hakamada, K.
,
Yamamoto, M.
,
Yamaue, H.
,
Eguchi, K.
,
Ichikawa, W.
,
Miyazaki
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 281 KB
Your tags:
english, 2015
18
Treatment effect of buparlisib, cetuximab and irradiation in wild-type orPI3KCA-mutated head and neck cancer cell lines
Lattanzio, Laura
,
Tonissi, Federica
,
Monteverde, Martino
,
Vivenza, Daniela
,
Russi, Elvio
,
Milano, Gérard
,
Merlano, Marco
,
Lo Nigro, Cristiana
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.26 MB
Your tags:
english, 2015
19
Phase 1 study of the oral histone deacetylase inhibitor abexinostat in patients with Hodgkin lymphoma, non-Hodgkin lymphoma, or chronic lymphocytic leukaemia
Morschhauser, Franck
,
Terriou, Louis
,
Coiffier, Bertrand
,
Bachy, Emmanuel
,
Varga, Andrea
,
Kloos, Ioana
,
Lelièvre, Hélène
,
Sarry, Anne-Laure
,
Depil, Stéphane
,
Ribrag, Vincent
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 772 KB
Your tags:
english, 2015
20
Chemotherapy with cytochalasin congeners in vitro and in vivo against murine models
Trendowski, Matthew
,
Mitchell, Joan M.
,
Corsette, Christine M.
,
Acquafondata, Christopher
,
Fondy, Thomas P.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 2.01 MB
Your tags:
english, 2015
21
Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors
Dickson, Mark A.
,
Gordon, Michael S.
,
Edelman, Gerald
,
Bendell, Johanna C.
,
Kudchadkar, Ragini R.
,
LoRusso, Patricia M.
,
Johnston, Stuart H.
,
Clary, Douglas O.
,
Schwartz, Gary K.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 609 KB
Your tags:
english, 2015
22
Phase I study of amatuximab, a novel monoclonal antibody to mesothelin, in Japanese patients with advanced solid tumors
Fujisaka, Yasuhito
,
Kurata, Takayasu
,
Tanaka, Kaoru
,
Kudo, Toshihiro
,
Okamoto, Kunio
,
Tsurutani, Junji
,
Kaneda, Hiroyasu
,
Okamoto, Isamu
,
Namiki, Masayuki
,
Kitamura, Chifumi
,
Nakagawa, Kazuhiko
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 537 KB
Your tags:
english, 2015
23
Phase I study of the novel Cdc2/CDK1 and AKT inhibitor terameprocol in patients with advanced leukemias
Tibes, R.
,
McDonagh, K. T.
,
Lekakis, L.
,
Bogenberger, J. M.
,
Kim, S.
,
Frazer, N.
,
Mohrland, S.
,
Bassett, D.
,
Garcia, R.
,
Schroeder, K.
,
Shanmugam, V.
,
Carpten, J.
,
Hagelstrom, R. T.
,
Beaudry, C.
,
Von
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 170 KB
Your tags:
english, 2015
24
A phase 1 dose escalation study of BI 831266, an inhibitor of Aurora kinase B, in patients with advanced solid tumors
Dittrich, Christian
,
Fridrik, Michael A.
,
Koenigsberg, Robert
,
Lee, Chooi
,
Goeldner, Rainer-Georg
,
Hilbert, James
,
Greil, Richard
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 2.44 MB
Your tags:
english, 2015
25
Phase 1b study of the oral gemcitabine ‘Pro-drug’ LY2334737 in combination with capecitabine in patients with advanced solid tumors
Infante, Jeffrey R.
,
Benhadji, Karim A.
,
Dy, Grace K.
,
Fetterly, Gerald
,
Ma, Wen Wee
,
Bendell, Johanna
,
Callies, Sophie
,
Adjei, Alex A.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 825 KB
Your tags:
english, 2015
26
First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors
LoRusso, Patricia M.
,
Goncalves, Priscila H.
,
Casetta, Lindsay
,
Carter, Judith A.
,
Litwiler, Kevin
,
Roseberry, Dale
,
Rush, Selena
,
Schreiber, Jennifer
,
Simmons, Heidi M.
,
Ptaszynski, Mieke
,
Sausville,
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 607 KB
Your tags:
english, 2015
27
Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMC-A12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors
Higano, C. S.
,
Berlin, J.
,
Gordon, M.
,
LoRusso, P.
,
Tang, S.
,
Dontabhaktuni, A.
,
Schwartz, J. D.
,
Cosaert, J.
,
Mehnert, J. M.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 457 KB
Your tags:
english, 2015
28
A phase 1 study of the sachet formulation of the oral dual PI3K/mTOR inhibitor BEZ235 given twice daily (BID) in patients with advanced solid tumors
Bendell, Johanna C.
,
Kurkjian, Carla
,
Infante, Jeffrey R.
,
Bauer, Todd M.
,
Burris, Howard A.
,
Greco, F. Anthony
,
Shih, Kent C.
,
Thompson, Dana S.
,
Lane, Cassie M.
,
Finney, Lindsey H.
,
Jones, Suzanne F
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.07 MB
Your tags:
english, 2015
29
Acknowledgement of Reviewers 2013
Journal:
Investigational New Drugs
Year:
2015
File:
PDF, 69 KB
Your tags:
2015
30
Acknowledgement of Reviewers 2014
Journal:
Investigational New Drugs
Year:
2015
File:
PDF, 77 KB
Your tags:
2015
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