Volume 33; Issue 4

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Investigational New Drugs
Volume 33; Issue 4

Investigational New Drugs

Volume 33; Issue 4

1

The effect of paclitaxel and nab-paclitaxel in combination with anti-angiogenic therapy in breast cancer cell lines

Tonissi, Federica, Lattanzio, Laura, Merlano, Marco C., Infante, Lucia, Lo Nigro, Cristiana, Garrone, Ornella

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 966 KB

english, 2015

2

Phase I study of ipilimumab in phased combination with paclitaxel and carboplatin in Japanese patients with non-small-cell lung cancer

Horinouchi, Hidehito, Yamamoto, Noboru, Fujiwara, Yutaka, Sekine, Ikuo, Nokihara, Hiroshi, Kubota, Kaoru, Kanda, Shintaro, Yagishita, Shigehiro, Wakui, Hiroshi, Kitazono, Satoru, Mizugaki, Hidenori, T

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 288 KB

english, 2015

3

A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer

Mitri, Zahi, Karakas, Cansu, Wei, Caimiao, Briones, Brian, Simmons, Holly, Ibrahim, Nuhad, Alvarez, Ricardo, Murray, James L., Keyomarsi, Khandan, Moulder, Stacy

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 529 KB

english, 2015

4

A phase II study of bevacizumab with modified OPTIMOX1 as first-line therapy for metastatic colorectal cancer: the TCOG-GI 0802 study

Nakayama, Norisuke, Sato, Atsushi, Tanaka, Soichi, Shimada, Ken, Konishi, Kazuo, Sasaki, Eisaku, Hibi, Kenji, Ichikawa, Hiroko, Kikuchi, Yoshinori, Sakuyama, Toshikazu, Sekikawa, Takashi, Hayashi, Kaz

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 597 KB

english, 2015

5

Phase 1 dose escalation trial of ilorasertib, a dual Aurora/VEGF receptor kinase inhibitor, in patients with hematologic malignancies

Garcia-Manero, Guillermo, Tibes, Raoul, Kadia, Tapan, Kantarjian, Hagop, Arellano, Martha, Knight, Emily A., Xiong, Hao, Qin, Qin, Munasinghe, Wijith, Roberts-Rapp, Lisa, Ansell, Peter, Albert, Daniel

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.12 MB

english, 2015

6

Pharmacokinetic assessment of dacomitinib (pan-HER tyrosine kinase inhibitor) in patients with locally advanced head and neck squamous cell carcinoma (LA SCCHN) following administration through a gastrostomy feeding tube (GT)

Chiu, Joanne W., Chan, Kelvin, Chen, Eric X., Siu, Lillian L., Abdul Razak, Albiruni R.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 226 KB

english, 2015

7

Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study

Pedersen, Katrina S., Kim, George P., Foster, Nathan R., Wang-Gillam, Andrea, Erlichman, Charles, McWilliams, Robert R.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 293 KB

english, 2015

8

Generation and tumor recognition properties of two human monoclonal antibodies specific to cell surface anionic phospholipids

Bujak, Emil, Pretto, Francesca, Neri, Dario

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 4.02 MB

english, 2015

9

Co-administration of antigen with chemokine MCP-3 or MDC/CCL22 enhances DNA vaccine potency

Xie, Xinmei, Wang, Lin, Yang, Wenliang, Yu, Ruishuang, Li, Qingli, Pang, Xiaobin

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 238 KB

english, 2015

10

A phase II study of the HDAC inhibitor SB939 in patients with castration resistant prostate cancer: NCIC clinical trials group study IND195

Eigl, B. J., North, S., Winquist, E., Finch, D., Wood, L., Sridhar, S. S., Powers, J., Good, J., Sharma, M., Squire, J. A., Bazov, J., Jamaspishvili, T., Cox, M. E., Bradbury, P. A., Eisenhauer, E. A.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 386 KB

english, 2015

11

In vitro and in vivo toxicity of 5-FdU-alendronate, a novel cytotoxic bone-seeking duplex drug against bone metastasis

Schott, Sarah, Vallet, Sonia, Tower, Robert J., Noor, Seema, Tiwari, Sanjay, Schem, Christian, Busch, Christian

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 2.28 MB

english, 2015

12

Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs

Schreiber-Brynzak, Ekaterina, Klapproth, Erik, Unger, Christine, Lichtscheidl-Schultz, Irene, Göschl, Simone, Schweighofer, Sarah, Trondl, Robert, Dolznig, Helmut, Jakupec, Michael A., Keppler, Bernha

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 4.71 MB

english, 2015

13

Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer

Collery, Philippe, Mohsen, Ahmed, Kermagoret, Anthony, Corre, Samantha, Bastian, Gérard, Tomas, Alain, Wei, Ming, Santoni, François, Guerra, Nadia, Desmaële, Didier, d’Angelo, Jean

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

14

Cytotoxicity of anthraquinones from the roots ofPentas schimperitowards multi-factorial drug-resistant cancer cells

Kuete, Victor, Donfack, Arno R. Nanfack, Mbaveng, Armelle T., Zeino, Maen, Tane, Pierre, Efferth, Thomas

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

15

First-in-human, phase I study of elisidepsin (PM02734) administered as a 30-min or as a 3-hour intravenous infusion every three weeks in patients with advanced solid tumors

Ratain, Mark J., Geary, David, Undevia, Samir D., Coronado, Cinthya, Alfaro, Vicente, Iglesias, Jorge L., Schilsky, Richard L., Miguel-Lillo, Bernardo

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 841 KB

english, 2015

16

Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer

Reddy, S. M., Kopetz, S., Morris, J., Parikh, N., Qiao, W., Overman, M. J., Fogelman, D., Shureiqi, I., Jacobs, C., Malik, Z., Jimenez, C. A., Wolff, R. A., Abbruzzese, J. L., Gallick, G., Eng, C.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 435 KB

english, 2015

17

Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the mayo phase II consortium and the cancer therapeutics research group (MC1079)

Ma, B. B. Y., Goh, B. C., Lim, W. T., Hui, E. P., Tan, E. H., Lopes, G. de Lima, Lo, K. W., Li, L., Loong, H., Foster, N. R., Erlichman, C., King, A. D., Kam, M. K. M., Leung, S. F., Chan, K. C., Chan

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 367 KB

english, 2015

18

Investigation of the impact of hepatic impairment on the pharmacokinetics of dacomitinib

Giri, Nagdeep, Masters, Joanna C., Plotka, Anna, Liang, Yali, Boutros, Tanya, Pardo, Patricia, O’Connell, Joseph, Bello, Carlo

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 509 KB

english, 2015

19

Amidation inhibitors 4-phenyl-3-butenoic acid and 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester are novel HDAC inhibitors with anti-tumorigenic properties

Ali, Amna, Burns, Timothy J., Lucrezi, Jacob D., May, Sheldon W., Green, George R., Matesic, Diane F.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 652 KB

english, 2015

20

Dose-finding study of hepatic arterial infusion of irinotecan-based treatment in patients with advanced cancers metastatic to the liver

Said, Rabih, Kurzrock, Razelle, Naing, Aung, Hong, David S., Fu, Siqing, Piha-Paul, Sarina A., Wheler, Jennifer J., Janku, Filip, Kee, Bryan K., Bidyasar, Savita, Lim, Joann, Wallace, Michael, Tsimber

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 330 KB

english, 2015

21

Targeting the plasma membrane of neoplastic cells through alkylation: a novel approach to cancer chemotherapy

Trendowski, Matthew, Fondy, Thomas P.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.46 MB

english, 2015

22

Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors

Do, Khanh, Speranza, Giovanna, Chang, Lun-Ching, Polley, Eric C., Bishop, Rachel, Zhu, Weimin, Trepel, Jane B., Lee, Sunmin, Lee, Min-Jung, Kinders, Robert J., Phillips, Larry, Collins, Jerry, Lyons,

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 671 KB

english, 2015

23

Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose

Venkatakrishnan, Karthik, Kim, Tae Min, Lin, Chia-Chi, Thye, Lim Soon, Chng, Wee Joo, Ma, Brigette, Chen, Ming Huang, Zhou, Xiaofei, Liu, Hua, Kelly, Virginia, Kim, Won Seog

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 468 KB

english, 2015

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