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Volume 33; Issue 5
Main
Investigational New Drugs
Volume 33; Issue 5
Investigational New Drugs
Volume 33; Issue 5
1
Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors
Zibelman, Matthew
,
Wong, Yu-Ning
,
Devarajan, Karthik
,
Malizzia, Lois
,
Corrigan, Alycia
,
Olszanski, Anthony J.
,
Denlinger, Crystal S.
,
Roethke, Susan K.
,
Tetzlaff, Colleen H.
,
Plimack, Elizabeth R.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.19 MB
Your tags:
english, 2015
2
Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells
Koubkova, Lucie
,
Vyzula, Rostislav
,
Karban, Jindrich
,
Pinkas, Jiri
,
Ondrouskova, Eva
,
Vojtesek, Borivoj
,
Hrstka, Roman
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 3.29 MB
Your tags:
english, 2015
3
P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib
de Gooijer, Mark C.
,
Zhang, Ping
,
Thota, Nishita
,
Mayayo-Peralta, Isabel
,
Buil, Levi C. M.
,
Beijnen, Jos H.
,
van Tellingen, Olaf
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1003 KB
Your tags:
english, 2015
4
Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer
Gustavsson, Bengt
,
Carlsson, Göran
,
Swartling, Torbjörn
,
Kurlberg, Göran
,
Derwinger, Kristoffer
,
Björkqvist, Hillevi
,
Odin, Elisabeth
,
Gibson, Fernando
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 407 KB
Your tags:
english, 2015
5
BRAF-mutated clear cell sarcoma is sensitive to vemurafenib treatment
Protsenko, Svetlana A.
,
Semionova, Anna I.
,
Komarov, Yuri I.
,
Aleksakhina, Svetlana N.
,
Ivantsov, Alexandr O.
,
Iyevleva, Aglaya G.
,
Imyanitov, Evgeny N.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 703 KB
Your tags:
english, 2015
6
Subcellular localization of anthracyclines in cultured rat cardiomyoblasts as possible predictors of cardiotoxicity
Studzian, Kazimierz
,
Kik, Krzysztof
,
Lukawska, Malgorzata
,
Oszczapowicz, Irena
,
Strek, Malgorzata
,
Szmigiero, Leszek
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 511 KB
Your tags:
english, 2015
7
Long term exposure to antiangiogenic therapy, bevacizumab, induces osteonecrosis
T. Tabouret
,
T. Gregory
,
M. Dhooge
,
C. Brezault
,
O. Mir
,
J. Dréanic
,
S. Chaussade
,
R. Coriat
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 375 KB
Your tags:
english, 2015
8
Ulcerative colitis in a patient with non-small-cell lung cancer receiving bevacizumab
Tanaka, Midori
,
Ishii, Hidenobu
,
Azuma, Koichi
,
Saisho, Chika
,
Matsuo, Norikazu
,
Imamura, Yohei
,
Tokito, Takaaki
,
Kinoshita, Takashi
,
Yamada, Kazuhiko
,
Takedatsu, Hidetoshi
,
Mitsuyama, Keiichi
,
Hoshin
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 585 KB
Your tags:
english, 2015
9
First-in-human study of the toxicity, pharmacokinetics, and pharmacodynamics of CG200745, a pan-HDAC inhibitor, in patients with refractory solid malignancies
K. Kim
,
S. J. Park
,
J. Kim
,
Y. S. Hong
,
J. Lee
,
K. Bae
,
H. Cha
,
S. Kwon
,
S. Ro
,
J. Cho
,
T. W. Kim
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 559 KB
Your tags:
english, 2015
10
Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer
Tolaney, Sara M.
,
Tan, Sally
,
Guo, Hao
,
Barry, William
,
Van Allen, Eliezer
,
Wagle, Nikhil
,
Brock, Jane
,
Larrabee, Katherine
,
Paweletz, Cloud
,
Ivanova, Elena
,
Janne, Pasi
,
Overmoyer, Beth
,
Wright, John
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 786 KB
Your tags:
english, 2015
11
Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer
Doi, Toshihiko
,
Yoshino, Takayuki
,
Fuse, Nozomu
,
Boku, Narikazu
,
Yamazaki, Kentaro
,
Koizumi, Wasaburo
,
Shimada, Ken
,
Takinishi, Yasutaka
,
Ohtsu, Atsushi
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 375 KB
Your tags:
english, 2015
12
A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors
S. F. Jones
,
L. L. Siu
,
J. C. Bendell
,
J. M. Cleary
,
A. R. A. Razak
,
J. R. Infante
,
S. S. Pandya
,
P. L. Bedard
,
K. J. Pierce
,
B. Houk
,
W. G. Roberts
,
S. M. Shreeve
,
G. I. Shapiro
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 334 KB
Your tags:
english, 2015
13
Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta
L. Roy
,
M. Poirier
,
D. Fortin
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.10 MB
Your tags:
english, 2015
14
Phase I trial of combination of FOLFIRI and pasireotide, a somatostatin analogue, in advanced gastrointestinal malignancies
Mahipal, Amit
,
Shibata, Dave
,
Siegel, Erin
,
Springett, Gregory
,
Almhanna, Khaldoun
,
Fulp, William
,
Williams-Elson, Irene
,
Kim, Richard
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 385 KB
Your tags:
english, 2015
15
Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis
Vanden Heuvel, John P.
,
Thompson, Jerry T.
,
Albrecht, Prajakta
,
Mandetta, Donald
,
Kamerow, Harry
,
Ford, John P.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 1.14 MB
Your tags:
english, 2015
16
A phase I/Ib study of trametinib (GSK1120212) alone and in combination with gemcitabine in Japanese patients with advanced solid tumors
Kasuga, Akiyoshi
,
Nakagawa, Kazuhiko
,
Nagashima, Fumio
,
Shimizu, Toshio
,
Naruge, Daisuke
,
Nishina, Shinichi
,
Kitamura, Hiroshi
,
Kurata, Takayasu
,
Takasu, Atsuko
,
Fujisaka, Yasuhito
,
Okamoto, Wataru
,
N
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 382 KB
Your tags:
english, 2015
17
Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors
Cercek, Andrea
,
Wheler, Jennifer
,
Murray, Peter E.
,
Zhou, Shawn
,
Saltz, Leonard
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 270 KB
Your tags:
english, 2015
18
Topotecan plus cyclophosphamide in adults with relapsed or refractory pediatric-type sarcoma: a retrospective analysis from the German Sarcoma Medical Oncology Group (AIO)
Hartmann, Jörg Thomas
,
Issels, R. D.
,
Nicolo, K. San
,
Grünwald, V.
,
Hertenstein, B.
,
Papesch, E.
,
Krause, S.
,
Sturm, I.
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 371 KB
Your tags:
english, 2015
19
Severe acute interstitial lung disease in a patient with anaplastic lymphoma kinase rearrangement–positive non–small cell lung cancer treated with alectinib
Yamamoto, Yuzo
,
Okamoto, Isamu
,
Otsubo, Kohei
,
Iwama, Eiji
,
Hamada, Naoki
,
Harada, Taishi
,
Takayama, Koichi
,
Nakanishi, Yoichi
Journal:
Investigational New Drugs
Year:
2015
Language:
english
File:
PDF, 406 KB
Your tags:
english, 2015
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