Volume 33; Issue 5

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Investigational New Drugs
Volume 33; Issue 5

Investigational New Drugs

Volume 33; Issue 5

1

Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors

Zibelman, Matthew, Wong, Yu-Ning, Devarajan, Karthik, Malizzia, Lois, Corrigan, Alycia, Olszanski, Anthony J., Denlinger, Crystal S., Roethke, Susan K., Tetzlaff, Colleen H., Plimack, Elizabeth R.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.19 MB

english, 2015

2

Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells

Koubkova, Lucie, Vyzula, Rostislav, Karban, Jindrich, Pinkas, Jiri, Ondrouskova, Eva, Vojtesek, Borivoj, Hrstka, Roman

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 3.29 MB

english, 2015

3

P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib

de Gooijer, Mark C., Zhang, Ping, Thota, Nishita, Mayayo-Peralta, Isabel, Buil, Levi C. M., Beijnen, Jos H., van Tellingen, Olaf

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1003 KB

english, 2015

4

Phase 1 dose de-escalation trial of the endogenous folate [6R]-5,10-methylene tetrahydrofolate in combination with fixed-dose pemetrexed as neoadjuvant therapy in patients with resectable rectal cancer

Gustavsson, Bengt, Carlsson, Göran, Swartling, Torbjörn, Kurlberg, Göran, Derwinger, Kristoffer, Björkqvist, Hillevi, Odin, Elisabeth, Gibson, Fernando

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 407 KB

english, 2015

5

BRAF-mutated clear cell sarcoma is sensitive to vemurafenib treatment

Protsenko, Svetlana A., Semionova, Anna I., Komarov, Yuri I., Aleksakhina, Svetlana N., Ivantsov, Alexandr O., Iyevleva, Aglaya G., Imyanitov, Evgeny N.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 703 KB

english, 2015

6

Subcellular localization of anthracyclines in cultured rat cardiomyoblasts as possible predictors of cardiotoxicity

Studzian, Kazimierz, Kik, Krzysztof, Lukawska, Malgorzata, Oszczapowicz, Irena, Strek, Malgorzata, Szmigiero, Leszek

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 511 KB

english, 2015

7

Long term exposure to antiangiogenic therapy, bevacizumab, induces osteonecrosis

T. Tabouret, T. Gregory, M. Dhooge, C. Brezault, O. Mir, J. Dréanic, S. Chaussade, R. Coriat

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 375 KB

english, 2015

8

Ulcerative colitis in a patient with non-small-cell lung cancer receiving bevacizumab

Tanaka, Midori, Ishii, Hidenobu, Azuma, Koichi, Saisho, Chika, Matsuo, Norikazu, Imamura, Yohei, Tokito, Takaaki, Kinoshita, Takashi, Yamada, Kazuhiko, Takedatsu, Hidetoshi, Mitsuyama, Keiichi, Hoshin

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 585 KB

english, 2015

9

First-in-human study of the toxicity, pharmacokinetics, and pharmacodynamics of CG200745, a pan-HDAC inhibitor, in patients with refractory solid malignancies

K. Kim, S. J. Park, J. Kim, Y. S. Hong, J. Lee, K. Bae, H. Cha, S. Kwon, S. Ro, J. Cho, T. W. Kim

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 559 KB

english, 2015

10

Phase II study of tivantinib (ARQ 197) in patients with metastatic triple-negative breast cancer

Tolaney, Sara M., Tan, Sally, Guo, Hao, Barry, William, Van Allen, Eliezer, Wagle, Nikhil, Brock, Jane, Larrabee, Katherine, Paweletz, Cloud, Ivanova, Elena, Janne, Pasi, Overmoyer, Beth, Wright, John

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 786 KB

english, 2015

11

Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer

Doi, Toshihiko, Yoshino, Takayuki, Fuse, Nozomu, Boku, Narikazu, Yamazaki, Kentaro, Koizumi, Wasaburo, Shimada, Ken, Takinishi, Yasutaka, Ohtsu, Atsushi

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 375 KB

english, 2015

12

A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors

S. F. Jones, L. L. Siu, J. C. Bendell, J. M. Cleary, A. R. A. Razak, J. R. Infante, S. S. Pandya, P. L. Bedard, K. J. Pierce, B. Houk, W. G. Roberts, S. M. Shreeve, G. I. Shapiro

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 334 KB

english, 2015

13

Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta

L. Roy, M. Poirier, D. Fortin

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.10 MB

english, 2015

14

Phase I trial of combination of FOLFIRI and pasireotide, a somatostatin analogue, in advanced gastrointestinal malignancies

Mahipal, Amit, Shibata, Dave, Siegel, Erin, Springett, Gregory, Almhanna, Khaldoun, Fulp, William, Williams-Elson, Irene, Kim, Richard

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 385 KB

english, 2015

15

Differential nucleobase protection against 5-fluorouracil toxicity for squamous and columnar cells: implication for tissue function and oncogenesis

Vanden Heuvel, John P., Thompson, Jerry T., Albrecht, Prajakta, Mandetta, Donald, Kamerow, Harry, Ford, John P.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

16

A phase I/Ib study of trametinib (GSK1120212) alone and in combination with gemcitabine in Japanese patients with advanced solid tumors

Kasuga, Akiyoshi, Nakagawa, Kazuhiko, Nagashima, Fumio, Shimizu, Toshio, Naruge, Daisuke, Nishina, Shinichi, Kitamura, Hiroshi, Kurata, Takayasu, Takasu, Atsuko, Fujisaka, Yasuhito, Okamoto, Wataru, N

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 382 KB

english, 2015

17

Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors

Cercek, Andrea, Wheler, Jennifer, Murray, Peter E., Zhou, Shawn, Saltz, Leonard

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 270 KB

english, 2015

18

Topotecan plus cyclophosphamide in adults with relapsed or refractory pediatric-type sarcoma: a retrospective analysis from the German Sarcoma Medical Oncology Group (AIO)

Hartmann, Jörg Thomas, Issels, R. D., Nicolo, K. San, Grünwald, V., Hertenstein, B., Papesch, E., Krause, S., Sturm, I.

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 371 KB

english, 2015

19

Severe acute interstitial lung disease in a patient with anaplastic lymphoma kinase rearrangement–positive non–small cell lung cancer treated with alectinib

Yamamoto, Yuzo, Okamoto, Isamu, Otsubo, Kohei, Iwama, Eiji, Hamada, Naoki, Harada, Taishi, Takayama, Koichi, Nakanishi, Yoichi

Journal:

Investigational New Drugs

Year:

2015

Language:

english

File:

PDF, 406 KB

english, 2015