Volume 34; Issue 2

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Investigational New Drugs
Volume 34; Issue 2

Investigational New Drugs

Volume 34; Issue 2

1

A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors andKRASmutant colorectal cancer

Deming, Dustin A., Cavalcante, Ludmila L., Lubner, Sam J., Mulkerin, Daniel L., LoConte, Noelle K., Eickhoff, Jens C., Kolesar, Jill M., Fioravanti, Suzanne, Greten, Tim F., Compton, Kathryn, Doyle, A

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 300 KB

english, 2016

2

Phase I trial of vandetanib in combination with gemcitabine and capecitabine in patients with advanced solid tumors with an expanded cohort in pancreatic and biliary cancers

Kessler, Elizabeth R., Eckhardt, S. Gail, Pitts, Todd M., Bradshaw-Pierce, Erica L., O’byrant, Cindy L., Messersmith, Wells A., Nallapreddy, Sujatha, Weekes, Colin, Spratlin, Jennifer, Lieu, Christoph

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 330 KB

english, 2016

3

Targeting BRAF mutants in clear-cell sarcomas of soft tissue: beyond sarcoma or melanoma classification

Uguen, Arnaud, Marcorelles, Pascale, De Braekeleer, Marc

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 207 KB

english, 2016

4

Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549

Silva, Izabella Thaís, Geller, Fabiana Cristina, Persich, Lara, Dudek, Sabine Eva, Lang, Karen Luise, Caro, Miguel Soriano Balparda, Durán, Fernando Javier, Schenkel, Eloir Paulo, Ludwig, Stephan, Sim

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 1.18 MB

english, 2016

5

Post-progression survival in patients with advanced hepatocellular carcinoma resistant to sorafenib

Ogasawara, Sadahisa, Chiba, Tetsuhiro, Ooka, Yoshihiko, Suzuki, Eiichiro, Kanogawa, Naoya, Saito, Tomoko, Motoyama, Tenyu, Tawada, Akinobu, Kanai, Fumihiko, Yokosuka, Osamu

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 592 KB

english, 2016

6

Pharmacokinetics, metabolism, and excretion of14C-labeled belinostat in patients with recurrent or progressive malignancies

Calvo, Emiliano, Reddy, Guru, Boni, Valentina, García-Cañamaque, Lina, Song, Tao, Tjornelund, Jette, Choi, Mi Rim, Allen, Lee F.

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 395 KB

english, 2016

7

Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats

Bao, Xuhui, Chandramohan, Vidyalakshmi, Reynolds, Randall P., Norton, John N., Wetsel, William C., Rodriguiz, Ramona M., Aryal, Dipendra K., McLendon, Roger E., Levin, Edward D., Petry, Neil A., Zalut

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 797 KB

english, 2016

8

A phase II study of cediranib, an oral VEGF inhibitor, in previously untreated patients with metastatic or recurrent malignant melanoma

McWhirter, Elaine, Quirt, Ian, Gajewski, Thomas, Pond, Gregory, Wang, Lisa, Hui, June, Oza, Amit

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 253 KB

english, 2016

9

Phase II study of amrubicin (SM-5887), a synthetic 9-aminoanthracycline, as first line treatment in patients with metastatic or unresectable soft tissue sarcoma: durable response in myxoid liposarcoma with TLS-CHOP translocation

Gupta, Sumati, Gouw, Launce, Wright, Jennifer, Chawla, Sant, Pitt, Debbie, Wade, Mark, Boucher, Ken, Sharma, Sunil

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 1.66 MB

english, 2016

10

The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15

Kinsella, Paula, Greene, Lisa M., Bright, Sandra A., Pollock, Jade K., Butini, Stefania, Campiani, Giuseppe, Bauer, Sebastian, Williams, D. Clive, Zisterer, Daniela M.

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 676 KB

english, 2016

11

An open-label, single-arm, phase 2 study of the Aurora kinase A inhibitor alisertib in patients with advanced urothelial cancer

Necchi, Andrea, Lo Vullo, Salvatore, Mariani, Luigi, Raggi, Daniele, Giannatempo, Patrizia, Calareso, Giuseppina, Togliardi, Elena, Crippa, Flavio, Di Genova, Nicola, Perrone, Federica, Colecchia, Mau

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 420 KB

english, 2016

12

A first-in-human dose-escalation study of the oral proteasome inhibitor oprozomib in patients with advanced solid tumors

Infante, Jeffrey R., Mendelson, David S., Burris, Howard A., Bendell, Johanna C., Tolcher, Anthony W., Gordon, Michael S., Gillenwater, Heidi H., Arastu-Kapur, Shirin, Wong, Hansen L., Papadopoulos, K

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 521 KB

english, 2016

13

Two randomized, double-blind, placebo-controlled, dose-escalation phase 1 studies evaluating BTH1677, a 1, 3–1,6 beta glucan pathogen associated molecular pattern, in healthy volunteer subjects

Halstenson, C. E., Shamp, T., Gargano, M. A., Walsh, R. M., Patchen, M. L.

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 510 KB

english, 2016

14

A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer

Kyriakopoulos, Christos E., Heath, Elisabeth I., Eickhoff, Jens C., Kolesar, Jill, Yayehyirad, Mulusew, Moll, Thomas, Wilding, George, Liu, Glenn

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 313 KB

english, 2016

15

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies

Cirkel, Geert A., Kerklaan, Bojana Milojkovic, Vanhoutte, Frédéric, der Aa, Annegret Van, Lorenzon, Giocondo, Namour, Florence, Pujuguet, Philippe, Darquenne, Sophie, de Vos, Filip Y. F., Snijders, To

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 616 KB

english, 2016

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