Volume 52; Issue 8

Journal of Clinical Pharmacology

Volume 52; Issue 8

1

Mechanistic Modeling of Antigen Sink Effect for Mavrilimumab Following Intravenous Administration in Patients With Rheumatoid Arthritis

Wang, Bing, Lau, Yvonne Y., Liang, Meina, Vainshtein, Inna, Zusmanovich, Mikhail, Lu, Hong, Magrini, Fabio, Sleeman, Matthew, Roskos, Lorin

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 5.52 MB

english, 2012

2

Cocktail Approach for In Vivo Phenotyping of 5 Major CYP450 Isoenzymes: Development of an Effective Sampling, Extraction, and Analytical Procedure and Pilot Study With Comparative Genotyping

Wohlfarth, Ariane, Naue, Jana, Lutz-Bonengel, Sabine, Dresen, Sebastian, Auwärter, Volker

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1008 KB

english, 2012

3

Pharmacokinetics and Safety of the Lopinavir/Ritonavir Tablet 500/125 mg Twice Daily Coadministered With Efavirenz in Healthy Adult Participants

Ng, Juki, Chiu, Yi-Lin, Awni, Walid, Bernstein, Barry, Causemaker, Sonja J., Klein, Cheri E.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 654 KB

english, 2012

4

Exposure-Clinical Response Analysis of Paricalcitol in Patients With Chronic Kidney Disease (Stage 5) on Hemodialysis or Peritoneal Dialysis

Noertersheuser, Peter A., Pradhan, Rajendra S., Klein, Cheri E., Williams, Laura A., Palaparthy, Rameshraja, Garimella, Tushar S., Lichtenberger, Olaf, Awni, Walid M.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.37 MB

english, 2012

5

Omeprazole Impairs the Absorption of Mycophenolate Mofetil But Not of Enteric-Coated Mycophenolate Sodium in Healthy Volunteers

Kees, M. G., Steinke, T., Moritz, S., Rupprecht, K., Paulus, E. M., Kees, F., Bucher, M., Faerber, L.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 855 KB

english, 2012

6

Population Pharmacokinetics of Pegaptanib in Patients With Neovascular, Age-Related Macular Degeneration

Basile, Anthony S., Hutmacher, Matt, Nickens, Dana, Nielsen, Jace, Kowalski, Ken, Whitfield, Lloyd, Masayo, Oishi, Nakane, Masami

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 918 KB

english, 2012

7

Author's Response

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 470 KB

english, 2012

8

Beneficial Effect of Vardenafil on Aortic Stiffness and Wave Reflections

Vlachopoulos, Charalambos, Terentes-Printzios, Dimitrios, Ioakeimidis, Nikolaos, Rokkas, Konstantinos, Samentzas, Alexios, Aggelis, Athanasios, Kardara, Despina, Stefanadis, Christodoulos

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 596 KB

english, 2012

9

Dosing Celecoxib in Pediatric Patients With Juvenile Rheumatoid Arthritis

Krishnaswami, Sriram, Hutmacher, Matt M., Robbins, Jeffery L., Bello, Akintunde, West, Christine, Bloom, Bradley J.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.35 MB

english, 2012

10

Improving the FDA's Advisory Committee Process

Brass, Eric P., Hiatt, William R.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 506 KB

english, 2012

11

Characterization of the Human QT Interval: Novel Distribution-Based Assessment of the Repolarization Effects of Moxifloxacin

Holzgrefe, Henry H., Ferber, Georg, Morrison, Royce, Meyer, Olivier, Greiter-Wilke, Andrea, Singer, Thomas

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.90 MB

english, 2012

12

Pharmacokinetics and Safety of Coadministered Oseltamivir and Rimantadine in Healthy Volunteers: An Open-Label, Multiple-Dose, Randomized, Crossover Study

Cirrincione-Dall, Georgina, Brennan, Barbara J., Ballester-Sanchis, Rosa M., Navarro, Mercidita T., Davies, Brian E.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 823 KB

english, 2012

13

Scientific Considerations for Pharmacoenhancers in Antiretroviral Therapy

Arya, Vikram, Robertson, Sarah M., Struble, Kimberly A., Murray, Jeffrey S.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 513 KB

english, 2012

14

Should Clinical Pharmacokinetic Bridging Studies Between Caucasian and Asian Populations Be Required for Approval of Monoclonal Antibodies?

Zhou, Honghui, Tsukamoto, Yuko, Davis, Hugh M.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 500 KB

english, 2012

15

Why Should Prediction Discrepancies Be Renamed Standardized Visual Predictive Check?

Comets, Emmanuelle, Brendel, Karl, Mentré, France

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 472 KB

english, 2012

16

Randomized 5-Treatment Crossover Study to Assess the Effects of External Heat on Serum Fentanyl Concentrations During Treatment With Transdermal Fentanyl Systems

Moore, Kenneth T., Sathyan, Gayatri, Richarz, Ute, Natarajan, Jaya, Vandenbossche, Joris

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 739 KB

english, 2012

17

Assessment of the Effects of Renal Impairment on the Pharmacokinetics of the Soluble Guanylate Cyclase Activator Cinaciguat After a Single Intravenous Dose

Lettieri, John T., Scheerans, Christian, Blunck, Martin, Mazzu, Arthur L., Frey, Reiner, Mück, Wolfgang, Sundaresan, Pavur R.

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 753 KB

english, 2012