Volume 32; Issue 3

Journal of Medicinal Chemistry

Volume 32; Issue 3

1

Portage transport of sulfanilamide and sulfanilic acid

Hwang, Se Young, Berges, David A., Taggart, John J., Gilvarg, Charles

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 732 KB

english, 1989

2

Studies on prodrugs. 10. Possible mechanism of N-dealkylation of N-masked norfloxacins having several active methylene groups

Kondo, Hirosato, Sakamoto, Fumio, Inoue, Yoshimasa, Tsukamoto, Goro

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 419 KB

english, 1989

3

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

Nakamura, Hideo, Kon, Tatsuya, Uno, Hitoshi, Nishikawa, Yoshinori, Shindo, Tokuhiko, Ishii, Katsumi

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.36 MB

english, 1989

4

Long acting dihydropyridine calcium antagonists. 2. 2-[2-aminoheterocycloethoxy]methyl derivatives

Arrowsmith, John E., Campbell, Simon F., Cross, Peter E., Burges, Roger A., Gardiner, Donald G.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 881 KB

english, 1989

5

Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationship of new 1-substituted derivatives

Bouzard, D., Di Cesare, P., Essiz, M., Jacquet, J. P., Remuzon, P., Weber, A., Oki, T., Masuyoshi, M.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 678 KB

english, 1989

6

3-Aminopyridazine derivatives with atypical antidepressant, serotonergic and dopaminergic activities

Wermuth, Camille Georges, Schlewer, Gilbert, Bourguignon, Jean Jacques, Maghioros, Georges, Bouchet, Marie Jeanne, Moire, Claudine, Kan, Jean Paul, Worms, Paul, Biziere, Kathleen

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.18 MB

english, 1989

7

2(1H)-Quinolinones with cardiac stimulant activity. 2. Synthesis and biological activities of 6-(N-linked, five-membered heteroaryl) derivatives

Alabaster, Colin T., Bell, Andrew S., Campbell, Simon F., Ellis, Peter, Henderson, Christopher G., Morris, David S., Roberts, David A., Ruddock, Keith S., Samuels, Gillian M. R., Stefaniak, Mark H.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.03 MB

english, 1989

8

Structure-activity studies of trichothecenes: cytotoxicity of analogs and reaction products derived from T-2 toxin and neosolaniol

Anderson, D. W., Black, R. M., Lee, C. G., Pottage, C., Rickard, R. L., Sandford, M. S., Webber, T. D., Williams, N. E.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.13 MB

english, 1989

9

Evaluation of glycolamide esters and various other esters of aspirin as true aspirin prodrugs

Moerk Nielsen, Niels, Bundgaard, Hans

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 887 KB

english, 1989

10

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

Hertzberg, Robert P., Caranfa, Mary Jo, Holden, Kenneth G., Jakas, Dalia R., Gallagher, Gregory, Mattern, Michael R., Mong, Shau Ming, Bartus, Joan O'Leary, Johnson, Randall K., Kingsbury, William D.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 746 KB

english, 1989

11

(6R,6S)-5,8,10-Trideaza-5,6,7,8-tetrahydrofolate and (6R,6S)-5,8,10-trideaza-5,6,7,8-tetrahydropteroyl-L-ornithine as potential antifolates and antitumor agents. 35

Rosowsky, Andre, Forsch, Ronald A., Moran, Richard G.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 990 KB

english, 1989

12

2H-[1]Benzopyrano[3,4-b]pyridines. Synthesis and activity at central monoamine receptors

Hutchison, Alan, Williams, Michael, De Jesus, Reynalda, Stone, George A., Sylvester, L., Clarke, Frank H., Sills, Matthew A.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.04 MB

english, 1989

13

Antitumor and antiviral activity of synthetic .alpha.- and .beta.-ribonucleosides of certain substituted pyrimido[5,4-d]pyrimidines: a new synthetic strategy for exocyclic aminonucleosides

Sanghvi, Yogesh S., Larson, Steven B., Matsumoto, Steven S., Nord, L. Dee, Smee, Donald F., Willis, Randall C., Avery, Thomas L., Robins, Roland K., Revankar, Ganapathi R.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.25 MB

english, 1989

14

New 4-(heteroanilido)piperidines, structurally related to the pure opioidagonist fentanyl, with agonist and/or antagonist properties

Bagley, Jerome R., Wynn, Richard L., Rudo, Frieda G., Doorley, Brian M., Spencer, H. Kenneth, Spaulding, Theodore

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.14 MB

english, 1989

15

Studies on prodrugs. 11. Synthesis and antimicrobial activity of N-[(4-methyl-5-methylene-2-oxo-1,3-dioxolan-4-yl)oxy]norfloxacin

Kondo, Hirosato, Sakamoto, Fumio, Uno, Toshio, Kawahata, Yoshihiro, Tsukamoto, Goro

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 467 KB

english, 1989

16

Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells

Chu, Chung K., Schinazi, Raymond F., Ahn, Moon K., Ullas, Giliyar V., Gu, Zi P.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 803 KB

english, 1989

17

Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogs of androsta-1,4-diene-3,17-dione

Sherwin, Paul F., McMullan, Patrick C., Covey, Douglas F.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.14 MB

english, 1989

18

A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

Palomino, Eduardo, Kessel, David, Horwitz, Jerome P.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 567 KB

english, 1989

19

Antitumor agents. 100. Inhibition of human DNA topoisomerase II by cytotoxic ether and ester derivatives of podophyllotoxin and .alpha.-peltatin

Thurston, Lee S., Imakura, Yasuhiro, Haruna, Mitsumasa, Li, De Hua, Liu, Zong Chao, Liu, Su Ying, Cheng, Yung Chi, Lee, Kuo Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 722 KB

english, 1989

20

Alkylating partial muscarinic agonists related to oxotremorine. N-[4-[(2-Haloethyl)methylamino]-2-butynyl]-5-methyl-2-pyrrolidones

Ringdahl, Bjorn, Roch, Margareth, Katz, Esther D., Frankland, Maria C.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 682 KB

english, 1989

21

3-(Aminoalkyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones as potential anticholinergic bronchodilators

Connor, David T., Unangst, Paul C., Schwender, Charles F., Sorenson, Roderick J., Carethers, Mary E., Puchalski, Chester, Brown, Richard E., Finkel, Martin P.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 716 KB

english, 1989

22

Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position

Marsham, Peter R., Chambers, Paula, Hayter, Anthony J., Hughes, Leslie R., Jackman, Ann L., O'Connor, Breda M., Bishop, Joel A. M., Calvert, A. Hilary

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 967 KB

english, 1989

23

Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3.beta.-ols

Haradahira, T., Schwendner, S. W., Kojima, M., Counsell, Raymond E.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 580 KB

english, 1989

24

The 2-desamino and 2-desamino-2-methyl analogs of aminopterin do not inhibit dihydrofolate reductase but are potently toxic to tumor cells in culture

Rosowsky, Andre, Forsch, Ronald A., Freisheim, James H., Moran, Richard G.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 512 KB

english, 1989

25

Crystallographic resolution and crystal and molecular structures of stereoisomers of 1,3,5-triglycidyl-s-triazinetrione

Hempel, Andrew, Camerman, Norman, Camerman, Arthur

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 496 KB

english, 1989

26

Synthesis and hypertensive activity of neuropeptide Y fragments and analogs with modified N- or C-termini or D-substitutions

Boublik, J. H., Scott, N. A., Brown, M. R., Rivier, J. E.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 714 KB

english, 1989

27

Synthesis and evaluation of iodinated analogs of diacylglycerols as potential probes for protein kinase C

Strawn, Laurie M., Martell, Robert E., Simpson, Robert U., Leach, Karen L., Counsell, Raymond E.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 781 KB

english, 1989

28

Masthead

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 159 KB

english, 1989

29

5-(1-Piperazinyl)-1H-1,2,4-triazol-3-amines as antihypertensive agents

Meyer, Walter E., Tomcufcik, Andrew S., Chan, Peter S., Haug, Margie

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 619 KB

english, 1989

30

New antitumor monoclonal antibody-vinca conjugates LY203725 and related compounds: design, preparation, and representative in vivo activity

Laguzza, Bennett C., Nichols, Cynthia L., Briggs, Stephen L., Cullinan, George J., Johnson, David A., Starling, James J., Baker, A. Leroy, Bumol, Thomas F., Corvalan, Jose R. F.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.07 MB

english, 1989

31

Preparation and antitumor activity of additional mitomycin A analogs

Sami, Salah M., Remers, William A., Bradner, William T.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 711 KB

english, 1989

32

In vitro metabolic transformations of vinblastine: oxidations catalyzed by peroxidase

Elmarakby, Sayed A., Duffel, Michael W., Goswami, Animesh, Sariaslani, F. Sima, Rosazza, John P. N.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 773 KB

english, 1989

33

Synthesis of gastrin antagonists, analogs of the C-terminal tetrapeptide of gastrin, by introduction of a .beta.-homo residue

Rodriguez, M., Fulcrand, P., Laur, J., Aumelas, A., Bali, J. P., Martinez, Jean

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 851 KB

english, 1989

34

Heterocyclic analogs of benzamide antiarrhythmic agents

Hanna, Reda, Lampe, John W., Lumma, William C., Erhardt, Paul W., Wong, Samuel S., Sullivan, Mark E.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 717 KB

english, 1989

35

1-(3-Cyano-2,3-dideoxy-.beta.-D-erythro-pentofuranosyl)thymine (cyanothymidine): synthesis and antiviral evaluation against human immunodeficiency virus

Greengrass, Colin W., Hoople, David W. T., Street, Stephen D. A., Hamilton, Fiona, Marriott, Michael S., Bordner, Jon, Dalgleish, Angus G., Mitsuya, Hiroaki, Broder, Samuel

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 665 KB

english, 1989

36

Dermorphin analogs carrying an increased positive net charge in their "message" domain display extremely high .mu.-opioid receptor selectivity

Schiller, Peter W., Nguyen Thi Mai Dung,, Chung, Nga N., Lemieux, Carole

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 883 KB

english, 1989

37

A carboxy-terminus truncated analog of angiotensin II, [Sar1]angiotensin II-(1-7)-amide, provides an entry to a new class of angiotensin II antagonists

Bovy, P. R., Trapani, A. J., McMahon, E. G., Palomo, M.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 402 KB

english, 1989

38

Synthesis and in vitro activity of 1.beta.-methyl C-2 quaternary heterocyclic alkylthio carbapenems

Kim, Choung Un, Luh, Bing Y., Misco, Peter F., Hitchcock, Michael J. M.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 508 KB

english, 1989

39

Synthesis of highly .mu. and .delta. opioid receptor-selective peptides containing a photoaffinity group

Landis, Geoffrey, Lui, George, Shook, Jennifer E., Yamamura, Henry I., Burks, Thomas F., Hruby, Victor J.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 909 KB

english, 1989

40

Preparation and biodistribution of 1-[2-(3-[125I]iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine and 1-[2-(3-[125I]iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine

Chumpradit, Sumalee, Kung, Hank F., Billings, Jeffrey, Guo, Yu Zhi, Wu, Yang, Shih, Jean

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 1.17 MB

english, 1989

41

A novel prodrug of an impermeant inhibitor of 3-deoxy-D-manno-2-octulosonate cytidylyltransferase has antibacterial activity

Norbeck, Daniel W., Rosenbrook, William, Kramer, James B., Grampovnik, David J., Lartey, Paul A.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 745 KB

english, 1989

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