Volume 33; Issue 5

Journal of Medicinal Chemistry

Volume 33; Issue 5

1

Synthesis and anticonvulsant activity of 1-phenylcyclohexylamine analogs

Thurkauf, Andrew, De Costa, Brian, Yamaguchi, Shunichi, Mattson, Mariena V., Jacobson, Arthur E., Rice, Kenner C., Rogawski, Michael A.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 817 KB

english, 1990

2

Nucleoside conjugates. 11. Synthesis and antitumor activity of 1-.beta.-D-arabinofuranosylcytosine and cytidine conjugates of thioether lipids

Hong, Chung Il, Kirisits, Alan J., Nechaev, Alexander, Buchheit, David J., West, Charles R.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 978 KB

english, 1990

3

Retinobenzoic acids. 5. Retinoidal activities of compounds having a trimethylsilyl or trimethylgermyl group(s) in human promyelocytic leukemia cells HL-60

Yamakawa, Takeru, Kagechika, Hiroyuki, Kawachi, Emiko, Hashimoto, Yuichi, Shudo, Koichi

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.13 MB

english, 1990

4

Synthesis, pharmacological effects, and conformation of 4,4-disubstituted 1,4-dihydropyridines

Goldmann, Siegfried, Born, Liborius, Kazda, Stanislav, Pittel, Bernd, Schramm, Matthias

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 777 KB

english, 1990

5

Polyamine analogs with antitumor activity

Edwards, Michael L., Prakash, N. J., Stemerick, D. M., Sunkara, S. P., Bitonti, A. J., Davis, G. F., Dumont, J. A., Bey, P.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 953 KB

english, 1990

6

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Atwal, Karnail S., Rovnyak, George C., Schwartz, Joseph, Moreland, Suzanne, Hedberg, Anders, Gougoutas, Jack Z., Malley, Mary F., Floyd, David M.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 765 KB

english, 1990

7

Novel benzamides as selective and potent gastric prokinetic agents. 1. Synthesis and structure-activity relationships of N-[(2-morpholinyl)alkyl]benzamides

Kato, Shiro, Morie, Toshiya, Hino, Katsuhiko, Kon, Tatsuya, Naruto, Shunsuke, Yoshida, Naoyuki, Karasawa, Tadahiko, Matsumoto, Junichi

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.12 MB

english, 1990

8

Synthesis and biological evaluation of prodrugs of zidovudine

Aggarwal, Sunil K., Gogu, Sudhir R., Rangan, S. R. S., Agrawal, Krishna C.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 814 KB

english, 1990

9

Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS

Norbeck, Daniel W., Kern, Earl, Hayashi, Seiji, Rosenbrook, William, Sham, Hing, Herrin, Thomas, Plattner, Jacob J., Erickson, John, Clement, Jacob

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 659 KB

english, 1990

10

The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives

Duncia, John V., Chiu, Andrew T., Carini, David J., Gregory, George B., Johnson, Alexander L., Price, William A., Wells, Gregory J., Wong, Pancras C., Calabrese, Joseph C., Timmermans, Pieter B. M. W.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 2.73 MB

english, 1990

11

Synthesis and antihyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones

Zask, Arie, Jirkovsky, Ivo, Nowicki, James W., McCaleb, Michael L.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 794 KB

english, 1990

12

Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids

Atwell, Graham J., Rewcastle, Gordon W., Baguley, Bruce C., Denny, William A.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 598 KB

english, 1990

13

Part VI. Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives

Carini, David J., Duncia, John V., Johnson, Alexander L., Chiu, Andrew T., Price, William A., Wong, Pancras C., Timmermans, Pieter B. M. W.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 941 KB

english, 1990

14

Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting antiischemic properties

Reiffen, Manfred, Eberlein, Wolfgang, Mueller, Peter, Psiorz, Manfred, Noll, Klaus, Heider, Joachim, Lillie, Christian, Kobinger, Walter, Luger, Peter

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.19 MB

english, 1990

15

Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogs of 10-substituted cannabidiol and 11- or 12-substituted .DELTA.8-tetrahydrocannabinol

Compton, David R., Little, Patrick J., Martin, Billy R., Gilman, Jeffery W., Saha, Jayanta K., Jorapur, Vaman S., Sard, Howard P., Razdan, Raj K.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.03 MB

english, 1990

16

(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme. 2. Terminal amino acid analogs of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline

Karanewsky, Donald S., Badia, Michael C., Cushman, David W., DeForrest, Jack M., Dejneka, Tamara, Lee, Ving G., Loots, Melanie J., Petrillo, Edward W.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.49 MB

english, 1990

17

Hypoxia-selective antitumor agents. 4. Relationships between structure, physicochemical properties, and hypoxia-selective cytotoxicity for nitracrine analogs with varying side chains: the "iminoacridan hypothesis"

Denny, William A., Atwell, Graham J., Anderson, Robert F., Wilson, William R.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.02 MB

english, 1990

18

Book Reviews

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 98 KB

english, 1990

19

Molecular design, synthesis, and antiinflammatory activity of a series of .beta.-aminoxypropionic acids

Macchia, Bruno, Balsamo, A., Lapucci, A., Macchia, F., Martinelli, A., Nencetti, S., Orlandini, E., Baldacci, M., Mengozzi, G.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 980 KB

english, 1990

20

Masthead

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 165 KB

english, 1990

21

Synthesis, conformation, and immunosuppressive activity of cyclosporines that contain .epsilon.-oxygen (4R)-4-[(E)-butenyl]-4,N-dimethyl-L-threonine analogs in the 1-position

Sun, Chong Qing, Guillaume, Dominique, Dunlap, Brian, Rich, Daniel H.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.47 MB

english, 1990

22

Structure-activity relationships for the carboxy-terminus-truncated analogs of angiotensin II, a new class of angiotensin II antagonists

Bovy, Philippe R., O'Neal, Joan M., Olins, Gillian M., Patton, Dennis R., McMahon, Ellen G., Palomo, Maria, Koepke, John P., Salles, Khadijeh S., Trapani, Angelo J.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 874 KB

english, 1990

23

Synthesis and biological activity of some derivatives of rifamycin P

Cavalleri, B., Turconi, M., Tamborini, G., Occelli, E., Cietto, G., Pallanza, R., Scotti, R., Berti, M., Romano, G., Parenti, F.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 756 KB

english, 1990

24

Antirhinovirus activity of 6-anilino-9-benzyl-2-chloro-9H-purines

Kelley, James L., Linn, James A., Selway, J. W. T.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 536 KB

english, 1990

25

Role of hydrogen bonding in ligand interaction with the N-methyl-D-aspartate receptor ion channel

Leeson, Paul D., Carling, Robert W., James, Kim, Smith, Julian D., Moore, Kevin W., Wong, Erik H. F., Baker, Raymond

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 2.67 MB

english, 1990

26

Synthesis and antitumor activity of 1-[[(dialkylamino)alkyl]amino]-4-methyl-5H-pyrido[4,3-b]benzo[e]- and -benzo[g])indoles. A new class of antineoplastic agents

Nguyen Chi Hung,, Lhoste, Jean Marc, Lavelle, Francois, Bissery, Marie Christine, Bisagni, Emile

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.13 MB

english, 1990

27

Receptor triggering and receptor regulation: structure-activity relationships from the receptor's point of view

Hollenberg, Morley D.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.61 MB

english, 1990

28

Synthesis and antimalarial activity of (+)-deoxoartemisinin

Jung, Mankil, Li, Xun, Bustos, Daniel A., ElSohly, Hala N., McChesney, James D., Milhous, Wilbur K.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 435 KB

english, 1990

29

Hydroxyethylamine analogs of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease

Rich, Daniel H., Green, Jeremy, Toth, Mihaly V., Marshall, Garland R., Kent, Stephen B. H.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 558 KB

english, 1990

30

Cytotoxicity and antitumor activity of some tetrahedral bis(diphosphino)gold(I) chelates

Berners-Price, Susan J., Girard, Gerald R., Hill, David T., Sutton, Blaine M., Jarrett, Penelope S., Faucette, Leo F., Johnson, Randall K., Mirabelli, Christopher K., Sadler, Peter J.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 975 KB

english, 1990

31

Studies on hindered phenols and analogs. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity

Aizawa, Yuichi, Kanai, Tsutomu, Hasegawa, Kazuo, Yamaguchi, Takeshi, Iizuka, Yoshio, Iwaoka, Teiki, Yoshioka, Takao

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 790 KB

english, 1990

32

Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II

Lee, Kuo Hsiung, Beers, Scott A., Mori, Masami, Wang, Zhe Qing, Kuo, Yao Haur, Li, Li, Liu, Su Ying, Chang, Jang Yang, Han, Fu Sheng, Cheng, Yung Chi

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 616 KB

english, 1990

33

N-(3-[18F]Fluoropropyl)-N-nordiprenorphine: synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography

Chesis, Paul L., Hwang, Dah Ren, Welch, Michael J.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.29 MB

english, 1990

34

Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogs derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one

Beres, J., Sagi, G., Tomoskozi, I., Gruber, L., Baitz-Gacs, E., Otvos, L., De Clercq, E.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.12 MB

english, 1990

35

Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells

Farrow, Stuart N., Jones, A. Stanley, Kumar, Ajit, Walker, Richard T., Balzarini, Jan, De Clercq, Erik

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.01 MB

english, 1990

36

Antitumor imidazotetrazines. 20. Preparation of the 8-acid derivative of mitozolomide and its utility in the preparation of active antitumor agents

Horspool, K. R., Stevens, M. F. G., Newton, Christopher G., Lunt, E., Walsh, R. J. A., Pedgrift, B. L., Baig, G. U., Lavelle, F., Fizames, C.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 761 KB

english, 1990

37

Renin inhibitory peptides. A .beta.-aspartyl residue as a replacement for the histidyl residue at the P-2 site

Thaisrivongs, Suvit, Mao, Boryeu, Pals, Donald T., Turner, Steve R., Kroll, Lisa T.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1007 KB

english, 1990

38

Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives

Bouzard, D., Di Cesare, P., Essiz, M., Jacquet, J. P., Kiechel, J. R., Remuzon, P., Weber, A., Oki, T., Masuyoshi, M.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 997 KB

english, 1990

39

A model for compounds active against human rhinovirus-14 based on x-ray crystallography data

Diana, Guy D., Treasurywala, Adi M., Bailey, Thomas R., Oglesby, Richard C., Pevear, Daniel C., Dutko, Frank J.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.74 MB

english, 1990

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